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Current Organic Chemistry

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ISSN (Online): 1875-5348

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Review Article

Palladium-catalyzed C-N Coupling Reactions in the Synthesis of Dibenzodiazepines

Author(s): Pooja Grewal and Navjeet Kaur*

Volume 26, Issue 20, 2022

Published on: 06 January, 2023

Page: [1813 - 1826] Pages: 14

DOI: 10.2174/1385272827666221228122631

Price: $65

Open Access Journals Promotions 2
Abstract

In today’s world, aryl halides have attracted our attention toward the amination reactions catalyzed by palladium. In this review article, there are some selected developments in the field of catalysis, and the Buchwald-Hartwig amination reaction is one of them. It is a common and highly efficient method reported for forming dibenzodiazepines. The readily accessible precursors and ammonia undergo cross-coupling reactions in the presence of a palladium catalyst; after that, the intermediate immediately undergoes intramolecular condensation to give the desired dibenzodiazepines in one step. Due to the structural characteristics of these compounds, the potential for diversification - principally for functional group incorporation - is immense. New and advanced technologies are also employed to form these medicinally important molecules and are reviewed here. Our purpose is to inform the researchers about recent advances in this protocol for the C-N bond formation, especially used for synthesizing dibenzodiazepines.

Keywords: Dibenzodiazepines, palladium, Pd(OAc)2, Pd2(dba)3, C-N coupling, amination reactions.

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