Title:Silymarin: A Phytoconstituent with Significant Therapeutic Potential - A
Narrative Review
Volume: 18
Issue: 2
Author(s): Sahil Sharma, Pravin Kumar*, Mahendra Singh Ashawat, Vinay Pandit, Chandrapal Singh Verma and Dinesh Kumar Sharma
Affiliation:
- Laureate Institute of Pharmacy, VPO-Kathog, Jwalamukhi, Kangra, H.P-176031, India
Keywords:
Silymarin, silybinin, dermatology, liver, skin, atopic dermatitis, cardiomyopathy.
Abstract: Silymarin, is a phytoactive constituent isolated from the fruits and seeds of Silybum marianum
L Gaetn.), also called milk thistle belonging to the family of Asteracease. The phytoactive has
been used to treat several physiological disorders. The objective of this manuscript was to review the
therapeutic prospective of silymarin due to its ability to treat several physiological disorders. The databases
such as Pubmed, Elsevier, and Google Scholar were reviewed for the investigations or reviews
published related to the title. The discussion is focused on the immunomodulatory, chemopreventive,
and anti-inflammatory mechanisms of silymarin in various metabolic and dermatological disorders. In
addition, the review discusses the different therapeutic potentials of silymarin such as the management
of the liver disorder, skin carcinogenesis, cardiovascular disorders, diabetes mellitus, neurodegenerative
disorders, and several dermatological disorders such as melasma, anti-aging, acne, rosacea, atopic
dermatitis, and psoriasis. Silymarin is safe even with a dose higher than the therapeutic dose. Silymarin
had good potential for the safe and effective treatment of numerous metabolic and dermatological
disorders.