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Current Nutrition & Food Science

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ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

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Review Article

Can we Reduce the Symptoms of Chronic Fatigue Syndrome by Regulating Micronutrients? A Review

Author(s): Gül Akduman, Emine Kurtbeyoğlu* and Fatma Esra Güneş

Volume 19, Issue 5, 2023

Published on: 03 February, 2023

Page: [509 - 518] Pages: 10

DOI: 10.2174/1573401319666221221102057

Price: $65

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Abstract

Introduction: Deficiencies of some micronutrients have been observed in chronic fatigue syndrome patients, but the underlying cause has not been fully understood. The aim of this study was to investigate whether there is a relationship between CFS and micronutrients.

Methods: Related articles searched the combinations of the following terms which were used for the search in the Web of Science database: “Chronic Fatigue Syndrome” OR “Chronic Fatigue- Fibromyalgia Syndrome” OR “Postviral Fatigue Syndrome” AND “vitamins” OR “minerals” OR “micronutrients”. Articles that met the inclusion criteria were included.

Results: The initial search resulted in 225 studies, with 11 studies fully meeting the inclusion criteria. In these studies, it has been shown that micronutrients may play a role in the etiology of CFS, and that supplemented micronutrients can positively affect the symptoms of CFS.

Conclusion: Although there seems to be a close relationship between CFS-related syndromes and nutritional status, the literature on this subject remains limited. The results of the studies were not compatible with each other due to differences in the studies. Therefore, new studies are needed to fully explain the relationship between CFS and micronutrients.

Keywords: Chronic fatigue syndrome, micronutrients, vitamins, minerals, cognitive impairment, autonomic dysfunction.

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[1]
Lakhan SE, Kirchgessner A. Gut inflammation in chronic fatigue syndrome. Nutr Metab 2010; 7(1): 79.
[http://dx.doi.org/10.1186/1743-7075-7-79] [PMID: 20939923]
[2]
Lim EJ, Ahn YC, Jang ES, Lee SW, Lee SH, Son CG. Systematic review and meta-analysis of the prevalence of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). J Transl Med 2020; 18(1): 100.
[http://dx.doi.org/10.1186/s12967-020-02269-0] [PMID: 32093722]
[3]
Johnston S, Staines D, Marshall-Gradisnik S. Epidemiological characteristics of chronic fatigue- syndrome/myalgic encephalomyelitis in Australian patients. Clin Epidemiol 2016; 8: 97-107.
[http://dx.doi.org/10.2147/CLEP.S96797] [PMID: 27279748]
[4]
Campagnolo N, Johnston S, Collatz A, Staines D, Marshall-Gradisnik S. Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: A systematic review. J Hum Nutr Diet 2017; 30(3): 247-59.
[http://dx.doi.org/10.1111/jhn.12435] [PMID: 28111818]
[5]
Werbach MR. Nutritional strategies for treating chronic fatigue syndrome. Altern Med Rev 2000; 5(2): 93-108.
[PMID: 10767667]
[6]
van Campen CLMC, Riepma K, Visser FC. Open trial of vitamin B12 nasal drops in adults with myalgic encephalomyelitis/chronic fatigue syndrome: Comparison of responders and non-responders. Front Pharmacol 2019; 10(9): 1102.
[http://dx.doi.org/10.3389/fphar.2019.01102] [PMID: 31616305]
[7]
Regland B, Forsmark S, Halaouate L, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One 2015; 10(4): e0124648.
[http://dx.doi.org/10.1371/journal.pone.0124648] [PMID: 25902009]
[8]
Ekua W. Brenu EWB. Methylation profile of CD4+ T cells in chronic fatigue syndrome/myalgic encephalomyelitis. J Clin Cell Immunol 2014; 5(3)
[http://dx.doi.org/10.4172/2155-9899.1000228]
[9]
de Vega WC, Vernon SD, McGowan PO. DNA methylation modifications associated with chronic fatigue syndrome. PLoS One 2014; 9(8): e104757.
[http://dx.doi.org/10.1371/journal.pone.0104757] [PMID: 25111603]
[10]
Suarez-Moreira E, Yun J, Birch CS, Williams JHH, McCaddon A, Brasch NE. Vitamin B(12) and redox homeostasis: Cob(II)alamin reacts with superoxide at rates approaching Superoxide Dismutase (SOD). J Am Chem Soc 2009; 131(42): 15078-9.
[http://dx.doi.org/10.1021/ja904670x] [PMID: 19799418]
[11]
Zhang X, Lu M, Xu Y, et al. IL-10 promoter hypomethylation is associated with increased IL-10 expression and poor survival in hepatocellular carcinoma. Transl Cancer Res 2019; 8(4): 1466-75.
[http://dx.doi.org/10.21037/tcr.2019.07.33] [PMID: 35116889]
[12]
Castro-Marrero J, Cordero MD, Segundo MJ, et al. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome? Antioxid Redox Signal 2015; 22(8): 679-85.
[http://dx.doi.org/10.1089/ars.2014.6181] [PMID: 25386668]
[13]
Plevin D, Galletly C. The neuropsychiatric effects of vitamin C deficiency: A systematic review. BMC Psychiatry 2020; 20(1): 315.
[http://dx.doi.org/10.1186/s12888-020-02730-w] [PMID: 32552785]
[14]
Kaminski M, Boal R. An effect of ascorbic acid on delayed-onset muscle soreness. Pain 1992; 50(3): 317-21.
[http://dx.doi.org/10.1016/0304-3959(92)90037-C] [PMID: 1280803]
[15]
Maes M, Mihaylova I, Bosmans E. Not in the mind of neurasthenic lazybones but in the cell nucleus: Patients with chronic fatigue syndrome have increased production of nuclear factor kappa beta. 2007. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17693979
[16]
Wei R, Christakos S. Mechanisms underlying the regulation of innate and adaptive immunity by vitamin D. Nutrients 2015; 7(10): 8251-60.
[http://dx.doi.org/10.3390/nu7105392] [PMID: 26404359]
[17]
Lorusso L, Mikhaylova SV, Capelli E, Ferrari D, Ngonga GK, Ricevuti G. Immunological aspects of chronic fatigue syndrome. Autoimmun Rev 2009; 8(4): 287-91.
[http://dx.doi.org/10.1016/j.autrev.2008.08.003] [PMID: 18801465]
[18]
Cortes Rivera M, Mastronardi C, Silva-Aldana C, Arcos-Burgos M, Lidbury B. Myalgic encephalomyelitis/chronic fatigue syndrome: a comprehensive review. Diagnostics 2019; 9(3): 91.
[http://dx.doi.org/10.3390/diagnostics9030091] [PMID: 31394725]
[19]
Turkulov V, Brkic S, Tomic S, Novakov Mikic A, Cebovic T, Turkulov V. Multivitamin mineral supplementation in patients with chronic fatigue syndrome. Med Sci Monit 2014; 20: 47-53.
[http://dx.doi.org/10.12659/MSM.889333] [PMID: 24419360]
[20]
Nicolson GL, Ellithorpe R. Lipid replacement and antioxidant nutritional therapy for restoring mitochondrial function and reducing fatigue in chronic fatigue syndrome and other fatiguing illnesses. J Chronic Fatigue Syndr 2006; 13(1): 57-68.
[http://dx.doi.org/10.1300/J092v13n01_06]
[21]
Wang M, Fu H, Xiao Y, et al. Effects of low-level organic selenium on lead-induced alterations in neural cell adhesion molecules. Brain Res 2013; 1530: 76-81.
[http://dx.doi.org/10.1016/j.brainres.2013.07.028] [PMID: 23892105]
[22]
Grant J, Veldee MS, Buchwald D. Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome. J Am Diet Assoc 1996; 96(4): 383-6.
[http://dx.doi.org/10.1016/S0002-8223(96)00104-6] [PMID: 8598441]
[23]
Outhoff K. Magnesium: Effects on physical and mental performance. S Afr Fam Pract 2018; 60(4): 32-4.
[http://dx.doi.org/10.4102/safp.v60i4.4902]
[24]
Maes M, Mihaylova I, De Ruyter M. Lower serum zinc in Chronic Fatigue Syndrome (CFS): Relationships to immune dysfunctions and relevance for the oxidative stress status in CFS. J Affect Disord 2006; 90(2-3): 141-7.
[http://dx.doi.org/10.1016/j.jad.2005.11.002] [PMID: 16338007]
[25]
Brouwers FM, Van Der Werf S, Bleijenberg G, Van Der Zee L, Van Der Meer JWM. The effect of a polynutrient supplement on fatigue and physical activity of patients with chronic fatigue syndrome: A double-blind randomized controlled trial. QJM 2002; 95(10): 677-83.
[http://dx.doi.org/10.1093/qjmed/95.10.677] [PMID: 12324640]
[26]
Ali A, Njike VY, Northrup V, et al. Intravenous micronutrient therapy (Myers’ Cocktail) for fibromyalgia: A placebo-controlled pilot study. J Altern Complement Med 2009; 15(3): 247-57.
[http://dx.doi.org/10.1089/acm.2008.0410] [PMID: 19250003]
[27]
Witham MD, Adams F, McSwiggan S, et al. Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome – A randomised controlled trial. Nutr Metab Cardiovasc Dis 2015; 25(3): 287-94.
[http://dx.doi.org/10.1016/j.numecd.2014.10.007] [PMID: 25455721]
[28]
De Lorenzo F, Hargreaves J, Kakkar VV. Phosphate diabetes in patients with chronic fatigue syndrome. Postgrad Med J 1998; 74(870): 229-32.
[http://dx.doi.org/10.1136/pgmj.74.870.229] [PMID: 9683977]
[29]
Heap LC, Peters TJ, Wessely S. Vitamin B status in patients with chronic fatigue syndrome. J R Soc Med 1999; 92(4): 183-5.
[http://dx.doi.org/10.1177/014107689909200405] [PMID: 10450194]
[30]
Sendur OF, Tastaban E, Turan Y, Ulman C. The relationship between serum trace element levels and clinical parameters in patients with fibromyalgia. Rheumatol Int 2008; 28(11): 1117-21.
[http://dx.doi.org/10.1007/s00296-008-0593-9] [PMID: 18496697]
[31]
Earl KE, Sakellariou GK, Sinclair M, et al. Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: A cohort study from the North-West of England. BMJ Open 2017; 7(11): e015296.
[http://dx.doi.org/10.1136/bmjopen-2016-015296] [PMID: 29118054]
[32]
Baklund IH, Dammen T, Moum TÅ, et al. Evaluating routine blood tests according to clinical symptoms and diagnostic criteria in individuals with myalgic encephalomyelitis/chronic fatigue syndrome. J Clin Med 2021; 10(14): 3105.
[http://dx.doi.org/10.3390/jcm10143105] [PMID: 34300271]

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