Title:Multifunctional Nanoparticles for Organelle-Specific Targeted Drug
Delivery in Cancer Therapy
Volume: 12
Issue: 3
Author(s): Surbhi Tomar, Vaibhav Rajoriya, Prashant Sahu, Shivangi Agarwal, Suresh P. Vyas and Sushil K. Kashaw*
Affiliation:
- Integrated Drug Discovery Research Laboratory, Department of Pharmaceutical Sciences, Dr. Harisingh Gour University
(A Central University), Sagar (MP), India
Keywords:
Cell organelles, targeted delivery, multifunctional nanoparticle, tumor cell, organelle-specific, lysosomes.
Abstract: Successful drug delivery with a carrier into the targeted organelles (nucleus, mitochondria,
lysosomes, etc.) is vital for achieving effective disease treatment. Nanoparticle (NP) based
drug delivery systems (NDDSs) depend on targeted delivery and are mainly focused on cellmembrane
targeting. In this review, we summarize research on multifunctional NPs with organellespecific
drug delivery. Different effective strategies are proposed for these nanoparticles functionalizing
by altering their chemical composition or by functional groups grafting onto their surface for
improving the ability of organelle targeting. Only when the released concentration of drugs becomes
high enough will they interact with specific organelles by molecular targets to induce apoptosis
of tumor cells. One of the prime goals for drug delivery research targeted is Organelle-specific
delivery.