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Review Article

与不同氧化还原失衡强度相关的细胞功能、保护性或损伤性反应：全面回顾

卷 30, 期 34, 2023

发表于: 20 January, 2023

页: [3927 - 3939] 页: 13

弟呕挨: 10.2174/0929867330666221209093343

价格: $65

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摘要

反应性物质（RS）在不同的浓度和暴露时间的有氧和厌氧细胞中产生，这可能会根据细胞抗氧化潜力和防御装置触发不同的反应。研究检索使用美国国立卫生研究院国家医学图书馆的PubMed数据库进行。细胞 RS 包括活性氧 （ROS）、氮 （RNS）、脂质 （RLS） 和亲电物质，它们决定了细胞稳态或功能失调的生物分子。氧化还原信号传导的复杂性与产生的RS的多样性，目标生物分子与RS的反应性，可用的抵消过程的多样性以及暴露时间有关。有利于前者的促氧化剂/抗氧化剂平衡的持续扭曲被定义为氧化应激，其强度决定了（i）在pM至nM范围内的RS水平的基础无害不平衡（氧化良性应激），支持生理过程（例如，免疫功能，甲状腺功能，胰岛素作用）和通过氧化还原信号对外部干预的有益反应;或（ii）RS水平超过氧化良应激区的过度毒性扭曲（氧化窘迫），导致生物分子的非特异性氧化及其功能丧失，导致细胞死亡和相关病理状态。细胞氧化还原失衡是一种复杂的现象，其潜在机制开始被理解，尽管RS如何启动细胞信号传导是一个有争议的问题。这方面的知识将更好地了解RS如何触发疾病的发病机制和进展，并发现未来的治疗措施。 插

关键词: 氧化还原失衡，氧化应激，生理功能，抗氧化，氧化窘迫，反应性物质。

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