Title:The Roles of IGF-1 and MGF on Nerve Regeneration under Hypoxia-
Ischemia, Inflammation, Oxidative Stress, and Physical Trauma
Volume: 24
Issue: 2
Author(s): Yongqiang Sha*, Liping Chen, Chunming Xu, Beibei Zhang, Huhai Hong and Chunli Wang*
Affiliation:
- Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen,
361021, China
- Hubei
Engineering Technology Research Center of Chinese Materia Medica Processing, College of Pharmacy, Hubei University
of Chinese Medicine, Wuhan, 430065, China
Keywords:
Insulin-like growth factor 1, mechano growth factor, peptide, IGF-1Ea, nerve regeneration, hypoxia, inflammation, cell apoptosis.
Abstract: Nerve injuries and lesions often lead to the loss of neural control, reducing the patients’
quality of lives. Nerve self-repair is difficult due to the low regeneration capacity, insufficient secretion
of neurotrophic factors, secondary complications, and adverse microenvironmental conditions such as
severe hypoxia-ischemia, inflammation, and oxidative stress. Effective therapies that can accelerate
nerve regeneration have been explored. Cytokine therapy can significantly improve neural survival and
myelin regeneration during nerve repair. Insulin-like growth factor-1 (IGF-1) and its isoforms (IGF-
1Ea and IGF-1Eb/Ec [also known as MGF]) represent a promising therapeutic approach regarding
nerve repair, given their well-described proliferative and anti-apoptotic capacities on neurons withstanding
the adverse environmental conditions. This review summarizes the research progress regarding
the effects of IGF-1 and its isoforms on nerve repair after nerve injury, hypoxic-ischemic insult,
inflammation, and oxidative stress. We provide a theoretical basis for the clinical treatment of nerve
injuries.