Title:The Role of Genetics and Synergistic Effect of Targeting Common Genetic
Mutations in Acute Lymphoblastic Leukemia (ALL)
Volume: 23
Issue: 14
Author(s): Niloofar Pilehvari, Maryam Katoueezadeh, Gholamhossein Hassanshahi, Seyedeh Atekeh Torabizadeh*Seyed Mohammad Torabizadeh
Affiliation:
- Pharmaceutics Research
Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Keywords:
Acute lymphoblastic leukemia, signaling pathways, genetic translocation, genetic mutations, gamma-ray irradiation, leukemogenesis.
Abstract: Increasing concern regarding non-treatment and relapse in Acute Lymphoblastic Leukemia
(ALL) among children and adults has attracted the attention of researchers to investigate
the genetic factors of ALL and discover new treatments with a better prognosis. Nevertheless, the
survival rate in children is more than in adults; therefore, it is necessary to find new potential molecular
targets with better therapeutic results. Genomic analysis has enabled the detection of different
genetic defects that are serious for driving leukemogenesis. The study of genetic translocation
provides a better understanding of the function of genes involved in disease progression. This
paper presents an overview of the main genetic translocations and dysregulations in the signaling
pathways of ALL. We also report the inhibitors of these main translocations and evaluate the synergistic
effect of chemical inhibitors and gamma-ray irradiation on ALL.