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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

DBU Mediated Efficient Synthesis of New N-(furan/thiophene/pyrrole-2-yl- (2-hydroxynaphthalen-1-yl)methyl)acetamides

Author(s): Kalyan Maram, Kowthalam Anitha, Reddymasu Sreenivasulu and Rudraraju Ramesh Raju*

Volume 20, Issue 7, 2023

Published on: 20 January, 2023

Page: [603 - 607] Pages: 5

DOI: 10.2174/1570178620666221207105947

Price: $65

Abstract

A series of N-(furan/thiophene/pyrrole-2-yl-(2-hydroxynaphthalen-1-yl)methyl) acetamide derivatives 4 has been depicted by one-pot three-component synthesis using 2- naphthol 1 with aldehydes 2 and amides 3 in the presence of DBU as a catalyst in ethanol as solvent under reflux condition for 110-120 min. This method has the advantages of good yields, being environmentally friendly, straightforward protocol, short reaction times, and mild reaction conditions.

Keywords: DBU, naphthol-furan/thiophene hybrids, eco-friendly, one-pot component reaction, MCRs, phenol.

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