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Review Article

了解腹主动脉瘤血管周围脂肪组织的潜在功能:研究现状和未来展望

卷 30, 期 40, 2023

发表于: 21 February, 2023

页: [4554 - 4568] 页: 15

弟呕挨: 10.2174/0929867330666221202142234

价格: $65

摘要

腹主动脉瘤(AAA)是发生在主动脉裂缝下方的血管壁进行性扩张，最好发生在肾动脉下方。AAA的分子机制尚未阐明。在过去的几十年里，对腹主动脉瘤的研究主要集中在血管壁上，普遍认为血管壁的炎症和中层断裂是AAA发生发展的核心步骤，而血管周围脂肪组织在AAA的发生发展中起着不可忽视的作用，PVAT的位置在血管壁上起着支撑和保护作用。但其位置的特殊性使其不仅具有内脏脂肪的生理功能;还可以通过分泌大量的脂肪因子和细胞因子来调节血管功能。腹主动脉瘤越来越高，血管破裂，抢救成功率低，死亡率极高。目前，还没有药物可以控制腹主动脉瘤的进展或逆转。因此，深入探讨腹主动脉瘤的发病机制，寻找抑制腹主动脉瘤形成和疾病进展的治疗新途径至关重要。腹主动脉瘤的主要特征是血管壁炎症和基质金属蛋白降解。本文就腹主动脉瘤血管周围脂肪组织释放的细胞因子进行综述，总结其调控腹主动脉瘤的机制，并为腹主动脉瘤的研究提供新的研究方向。

关键词: AAA, PVAT，高血压，脂肪因子，炎症，分子机制。

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