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Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Review Article

Prevention of Oxidative Stress and Diseases by Antioxidant Supplementation

Author(s): Giovanni Martemucci, Piero Portincasa, Vincenzo Centonze, Michele Mariano, Mohamad Khalil* and Angela Gabriella D'Alessandro

Volume 19, Issue 6, 2023

Published on: 26 December, 2022

Page: [509 - 537] Pages: 29

DOI: 10.2174/1573406419666221130162512

Abstract

Excessive and uncontrolled oxidative stress can damage biomacromolecules, such as lipids, proteins, carbohydrates, and DNA, by free radical and oxidant overproduction. In this review, we critically discuss the main properties of free radicals, their implications in oxidative stress, and specific pathological conditions. In clinical medicine, oxidative stress can play a role in several chronic noncommunicable diseases, such as diabetes mellitus, cardiovascular, inflammatory, neurodegenerative diseases, and tumours. Antioxidant supplements can theoretically prevent or stop the progression of diseases, but a careful literature analysis finds that more evidence is needed to dissect the ultimate beneficial effect of antioxidants versus reactive oxygen species in several diseases.

Keywords: Free radicals, oxidative stress, antioxidants, oxidative damage, diseases, reactive oxygen species.

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