Current Drug Delivery Strategies for Buccal Cavity Ailments using Mouth
Dissolving Wafer Technology: A Comprehensive Review on the Present
State of the Art

Bani   Kumar   Jana; Mohini      Singh; Rajat   Subhra   Dutta; Bhaskar      Mazumder
doi:10.2174/1567201820666221128152010
Abstract

Background: Mouth-dissolving wafer is polymer-based matrice that incorporates various pharmaceutical agents for oral drug delivery. This polymeric wafer is ingenious in the way that it needs not be administered with water, like in conventional tablet dosage form. It has better compliance among the pediatric and geriatric groups owing to its ease of administration.
Objective: The polymeric wafer dissolves quickly in the oral cavity and is highly effective for a targeted local effect in buccal-specific ailments. It is a safe, effective, and versatile drug delivery carrier for a range of drugs used to treat a plethora of oral cavity-specific ailments that inflict common people, like thrush, canker sores, periodontal disease, benign oral cavity tumors, buccal neoplasm, and malignancies. This review paper focuses thoroughly on the present state of the art in mouth-dissolving wafer technology for buccal drug delivery and targeting. Moreover, we have also addressed present-time limitations associated with wafer technology to aid researchers in future developments in the arena of buccal drug delivery.
Conclusion: This dynamic novel formulation has tremendous future implications for designing drug delivery systems to target pernicious ailments and diseases specific to the buccal mucosa. In a nutshell, this review paper aims to summarize the present state of the art in buccal targeted drug delivery.
Keywords: Mouth dissolving wafers, trans-mucosal route, oral administration, buccal cavity ailments, squamous cell carcinomas, erythroplakia and leukoplakia, mucoepidermoid carcinoma, oral thrush.
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DOI https://dx.doi.org/10.2174/1567201820666221128152010	Print ISSN 1567-2018
Publisher Name Bentham Science Publisher	Online ISSN 1875-5704