Gut Microbiome and Insomnia: A Mini-Review

Noor      Yaser Asaad; Maram      Walid Ballan; Heba   Yead Abdel-Latif   Shalabi; Ashfaque      Hossain

doi:10.2174/04666221122085900

Abstract

Background: The gut microbiome (microorganisms present in our gut) has emerged as an important determinative factor in a variety of diseases and health conditions. One new area in which the role of the gut microbiome is of intense interest is its role in various neurological manifestations, including insomnia, the most common sleep disorder. In this mini-review, we aim to highlight the latest research developments concerning the association between the gut microbiome and insomnia and summarize gut-brain interaction for a better understanding of the role of microbiota in insomnia.

Methods: Our search results included publications written in English from the year 2010 up to the year 2022. We used Pubmed, Google Scholar, and ScienceDirect to search for original articles pertaining to the relationship between the gut microbiome and insomnia using the following search terms: “Gut-brain Axis and Insomnia,” “Brain and Gut Microbiome,” ” Gut-brain Homeostasis”, and “Circadian Rhythm and Gut Microbiome”. Relevant articles from the reference list were reviewed in order to collect additional information.

Results: Studies have shown that the microbiome-gut-brain axis is thus associated with the development of insomnia. The gut microbiome can have an important role in the development of insomnia. On the other hand, insomnia can also modulate the gut microbiome. However, scientific work in this field is limited as relevant scientific research is at the initial state.

Conclusion: Bacteria present in the gut send signals to the brain via the vagus nerve by stimulating the afferent neurons of the enteric nervous system and influencing sleep quality and stress reactivity of the hypothalamic-pituitary-adrenal axis. The gut microbiome also communicates with the nervous system via the neuroendocrine pathway through various metabolic products. Insomnia also influences the structure and function of the gut microbiome.

Keywords: Microbiome, Dysbiosis, Insomnia, Somnogenic, Insomnogenic, Anti-inflammatory, Pro-inflammatory.

[1]
Smith RP, Easson C, Lyle SM. Gut microbiome diversity is associated with sleep physiology in humans. Plos One  2019; 2014(14): e0222394.
 [http://dx.doi.org/10.1371/journal.pone.0222394]

[2]
Burman D, Muzumdar H. Sleep architecture and physiology. In: Chopra A, Das P, Doghramji K, Eds. Management of sleep disorders in psychiatry.  Oxford, UK: Oxford University Press 2020; pp. 12-22.
 [http://dx.doi.org/10.1093/med/9780190929671.003.0002]

[3]
Krahn LE, Arand DL, Avidan AY, et al. Recommended protocols for the multiple sleep latency test and maintenance of wakefulness test in adults: Guidance from the American Academy of Sleep Medicine. J Clin Sleep Med  2021; 17(12): 2489-98.
 [http://dx.doi.org/10.5664/jcsm.9620] [PMID: 34423768]

[4]
Jehan S, Myers AK, Zizi F, et al. Sleep health disparity: The putative role of race, ethnicity and socioeconomic status. Sleep Med Disord  2018; 2: 127-33.

[5]
Buysse DJ. Insomnia. JAMA  2013; 309(7): 706-16.
 [http://dx.doi.org/10.1001/jama.2013.193] [PMID: 23423416]

[6]
Cresci GA, Bawden E. Gut Microbiome. Nutr Clin Pract  2015; 30(6): 734-46.
 [http://dx.doi.org/10.1177/0884533615609899] [PMID: 26449893]

[7]
Sekirov I, Russell SL, Antunes LCM, Finlay BB. Gut microbiota in health and disease. Physiol Rev  2010; 90(3): 859-904.
 [http://dx.doi.org/10.1152/physrev.00045.2009] [PMID: 20664075]

[8]
Manley GCA, Lee YK, Zhang Y. Gut microbiota and immunology of the gastrointestinal tract. In: Clin Basic Neurogastroenterol Motility.  Elsevier: Academic Press 2020; pp. 63-78.

[9]
Clemente JC, Ursell LK, Parfrey LW, Knight R. The impact of the gut microbiota on human health: An integrative view. Cell  2012; 148(6): 1258-70.
 [http://dx.doi.org/10.1016/j.cell.2012.01.035] [PMID: 22424233]

[10]
Feng Y, Fu S, Li C, et al. Interaction of gut microbiota and brain function in patients with chronic insomnia: A regional homogeneity study. Front Neurosci  2022; 15: 804843.
 [http://dx.doi.org/10.3389/fnins.2021.804843]

[11]
Rutsch A, Kantsjö JB, Ronchi F. The Gut-Brain Axis: How microbiota and host inflammasome influence brain physiology and pathology. Front Immunol  2020; 11: 604179.
 [http://dx.doi.org/10.3389/fimmu.2020.604179] [PMID: 33362788]

[12]
Zhang Y, Xie B, Chen X, Zhang J, Yuan S. A key role of gut microbiota-vagus nerve/spleen axis in sleep deprivation-mediated aggravation of systemic inflammation after LPS administration. Life Sci  2021; 265: 118736.
 [http://dx.doi.org/10.1016/j.lfs.2020.118736]

[13]
Morais LH, Schreiber HL IV, Mazmanian SK. The gut microbiota–brain axis in behaviour and brain disorders. Nat Rev Microbiol  2021; 19(4): 241-55.
 [http://dx.doi.org/10.1038/s41579-020-00460-0] [PMID: 33093662]

[14]
Mayer EA. Gut feelings: The emerging biology of gut–brain communication. Nat Rev Neurosci  2011; 12(8): 453-66.
 [http://dx.doi.org/10.1038/nrn3071] [PMID: 21750565]

[15]
Grosso G. Nutritional psychiatry: How diet affects brain through gut microbiota. Nutrients  2021; 13(4): 1282.
 [http://dx.doi.org/10.3390/nu13041282] [PMID: 33919680]

[16]
Chakrabarti A, Geurts L, Hoyles L, et al. The microbiota-gut-brain axis: Pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice. Cell Mol Life Sci  2022; 79(2): 80.
 [http://dx.doi.org/10.1007/s00018-021-04060-w]

[17]
Yoo BB, Mazmanian SK. The enteric network: Interactions between the immune and nervous systems of the gut. Immunity  2017; 46(6): 910-26.
 [http://dx.doi.org/10.1016/j.immuni.2017.05.011] [PMID: 28636959]

[18]
Zhang YJ, Li S, Gan RY, Zhou T, Xu DP, Li HB. Impacts of gut bacteria on human health and diseases. Int J Mol Sci  2015; 16(12): 7493-519.
 [http://dx.doi.org/10.3390/ijms16047493] [PMID: 25849657]

[19]
Jiang Z, Zhuo LB, He Y, et al. The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases. Nat Commun  2022; 13(1): 3002.
 [http://dx.doi.org/10.1038/s41467-022-30712-x]

[20]
Eban-Rothschild A, Appelbaum L, de Lecea L. Neuronal mechanisms for sleep / wake regulation and modulatory drive. Neuropsychopharmacology  2018; 43(5): 937-52.
 [http://dx.doi.org/10.1038/npp.2017.294] [PMID: 29206811]

[21]
Levenson JC, Kay DB, Buysse DJ. The pathophysiology of insomnia. Chest  2015; 147(4): 1179-92.
 [http://dx.doi.org/10.1378/chest.14-1617] [PMID: 25846534]

[22]
Li Y, Yanli H, Fang F, Zhang B. The role of microbiome in insomnia, circadian disturbance and depression. Front Psychiatry  2018; 9: 669.
 [http://dx.doi.org/10.3389/fpsyt.2018.00669]

[23]
Szentirmai É, Millican NS, Massie AR, Kapás L. Butyrate, a metabolite of intestinal bacteria, enhances sleep. Sci Rep  2019; 9(1): 7035.
 [http://dx.doi.org/10.1038/s41598-019-43502-1] [PMID: 31065013]

[24]
Heijtz RD, Wang S, Anuar F, et al. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci USA  2011; 108(7): 3047-52.
 [http://dx.doi.org/10.1073/pnas.1010529108] [PMID: 21282636]

[25]
Kennedy PJ, Cryan JF, Dinan TG, Clarke G. Kynurenine pathway metabolism and the microbiota gut brain axis. Neuropharmacology  2017; 112(Pt B): 399-412.
 [http://dx.doi.org/10.1016/j.neuropharm.2016.07.002] [PMID: 27392632]

[26]
Wagner-Skacel J, Dalkner N, Moerkl S, et al. Sleep and microbiome psychiatric diseases. Nutrients  2020; 12(8): 2198.
 [http://dx.doi.org/10.3390/nu12082198] [PMID: 32718072]

[27]
Zhang Q, Yun Y, An H, et al. Gut microbiome composition associated with major depressive disorder and sleep quality. Front Psychiatry  2021; 2: 645045.
 [http://dx.doi.org/10.3389/fpsyt.2021.645045]

[28]
Ogawa Y, Miyoshi C, Obana N, et al. Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice. Sci Rep  2020; 10(1): 19554.
 [http://dx.doi.org/10.1038/s41598-020-76562-9] [PMID: 33177599]

[29]
Brown R, Andrews K, Brown L, et al. Muramyl peptides and the functions of sleep. Behav Brain Res  1995; 69(1-2): 85-90.
 [http://dx.doi.org/10.1016/0166-4328(95)00004-D] [PMID: 7546321]

[30]
Lendrum J, Seebach B, Kher BA. Sleep and the gut microbiome: Antibiotic-induced depletion of the gut microbiota reduces nocturnal sleep in mice. bioRvix  2017; 2017: 199075.
 [http://dx.doi.org/10.1101/199075]

[31]
Benedict C, Vogel H, Jonas W, et al. Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals. Mol Metab  2016; 5(12): 1175-86.
 [http://dx.doi.org/10.1016/j.molmet.2016.10.003] [PMID: 27900260]

[32]
Bishehsari F, Voigt RM, Keshavarzian A. Circadian rhythms and the gut microbiota: From the metabolic syndrome to cancer. Nat Rev Endocrinol  2020; 16(12): 731-9.
 [http://dx.doi.org/10.1038/s41574-020-00427-4] [PMID: 33106657]

[33]
Gutierrez Lopez DE, Lashinger LM, Weinstock GM, Bray MS, Bray MS. Circadian rhythms and the gut microbiome synchronize the host’s metabolic response to diet. Cell Metab  2021; 33(5): 873-87.
 [http://dx.doi.org/10.1016/j.cmet.2021.03.015] [PMID: 33789092]

[34]
Voigt RM, Forsyth CB, Green SJ, Engen PA, Keshavarzian A. Circadian rhythm and the gut microbiome. Int Rev Neurobiol  2016; 131: 193-205.
 [http://dx.doi.org/10.1016/bs.irn.2016.07.002] [PMID: 27793218]

[35]
Han M, Yuan S, Zhang J. The interplay between sleep and gut microbiota. Brain Res Bull  2022; 180: 131-46.
 [http://dx.doi.org/10.1016/j.brainresbull.2021.12.016] [PMID: 35032622]

[36]
Reynolds AC, Paterson JL, Ferguson SA, et al. The shift work and health research agenda: Considering changes in gut microbiota as a pathway linking shift work, sleep loss and circadian misalignment, and metabolic disease. Sleep Med Rev  2017; 34: 3-9.
 [http://dx.doi.org/10.1016/j.smrv.2016.06.009]

[37]
Parkar SG, Kalsbeek A, Cheeseman JF. Potential role for the gut microbiota in modulating host circadian rhythms and metabolic health. Microorganisms  2019; 7: 41.
 [http://dx.doi.org/10.3390/microorganisms7020041]

[38]
Matenchuk BA, Mandhane PJ, Kozyrskyj AL. Sleep, circadian rhythm, and gut microbiota. Sleep Med Rev  2020; 53: 101340.
 [http://dx.doi.org/10.1016/j.smrv.2020.101340] [PMID: 32668369]

[39]
Liu Z, Wei ZY, Chen J, et al. Acute sleep-wake cycle shift results in community alteration of human gut microbiome. MSphere  2020; 5(1): e00914-19.
 [http://dx.doi.org/10.1128/mSphere.00914-19] [PMID: 32051239]

[40]
Rowland I, Gibson G, Heinken A, et al. Gut microbiota functions: Metabolism of nutrients and other food components. Eur J Nutr  2018; 57(1): 1-24.
 [http://dx.doi.org/10.1007/s00394-017-1445-8] [PMID: 28393285]

[41]
Kang Y, Kang X, Cai Y. The gut microbiome as a target for adjuvant therapy in insomnia disorder. Clin Res Hepatol Gastroenterol  2022; 46(1): 101834.
 [http://dx.doi.org/10.1016/j.clinre.2021.101834] [PMID: 34800683]

[42]
Dos Reis Lucena L, Terra Loyola V, Leopoldino de Bortolli C, Levy Andersen M, Tufik S, Hachul H. Effects of supplementation with Lactobacillus probiotics on insomnia treatment. Altern Ther Health Med  2021; 27(S1): 178-84.
 [PMID: 33609341]

[43]
Qi X, Ye J, Wen Y, et al. Evaluating the effects of diet-gut microbiota interactions on sleep traits using the UK biobank cohort. Nutrients  2022; 14(6): 1134.
 [http://dx.doi.org/10.3390/nu14061134] [PMID: 35334789]

[44]
Leeming ER, Johnson AJ, Spector TD, Le Roy CI. Effect of diet on the gut microbiota: Rethinking intervention duration. Nutrients  2019; 11(12): 2862.
 [http://dx.doi.org/10.3390/nu11122862] [PMID: 31766592]

[45]
Scoditti E, Tumolo MR, Garbarino S. Mediterranean diet on sleep: A health alliance. Nutrients  2022; 14(14): 2998.
 [http://dx.doi.org/10.3390/nu14142998]

[46]
Sen P, Molinero-Perez A, O’Riordan KJ, McCafferty CP, O’Halloran KD, Cryan JF. Microbiota and sleep: Awakening the gut feeling. Trends Mol Med  2021; 27(10): 935-45.
 [http://dx.doi.org/10.1016/j.molmed.2021.07.004] [PMID: 34364787]

[47]
Grosicki GJ, Riemann BL, Flatt AA, Valentino T, Lustgarten MS. Self-reported sleep quality is associated with gut microbiome composition in young, healthy individuals: A pilot study. Sleep Med  2020; 73: 76-81.
 [http://dx.doi.org/10.1016/j.sleep.2020.04.013] [PMID: 32795890]

[48]
Wang Z, Yuan K, Ji YB, et al. Alterations of the gut microbiota in response to total sleep deprivation and recovery sleep in mice. Nat Sci Sleep  2022; 14: 121-33.
 [http://dx.doi.org/10.2147/NSS.S334985] [PMID: 35115853]

[49]
Besedovsky L, Lange T, Haack M. The Sleep-immune crosstalk in health and disease. Physiol Rev  2019; 99(3): 1325-80.
 [http://dx.doi.org/10.1152/physrev.00010.2018] [PMID: 30920354]

[50]
Poroyko VA, Carreras A, Khalyfa A, et al. Chronic sleep disruption alters gut microbiota, induces systemic and adipose tissue inflammation and insulin resistance in mice. Sci Rep  2016; 6(1): 35405.
 [http://dx.doi.org/10.1038/srep35405] [PMID: 27739530]