Title:Prevalence and Transmission of Multi Drug Resistance Gene in Staphylococcus
aureus
Volume: 11
Issue: 3
Author(s): Bijayata Patra, Tamalika Chakraborty*Sutripto Ghosh
Affiliation:
- Department of Lifescience, Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, West Bengal, India
Keywords:
Multi drug resistant genes, antibiotic resistance, Staphylococcus aureus, drug resistant pathogens, ESKAPE pathogens, transposon, staphylococcal cassette chromosome.
Abstract: Antibiotics are antimicrobial substances that are commonly used to treat humans, animals,
and fish, as well as to research susceptibility patterns in a variety of bacteria. With the rising
number of diseases and the emergence of new infections, many drugs for humans, animals, fish, and
plants are being developed. However, with the development of pharmaceuticals came the advent of
a phenomenon known as drug resistance, which has alarmed scientists and researchers all around
the world. The building of resistance in genes that code for specific drugs, plasmids, or transposons,
the action of multidrug efflux pumps, changes in chromosomal genes, or the Staphylococci cassette
chromosome can all produce it. Staphylococcus aureus, the most common Gram-positive bacteria,
has a multidrug-resistant phenotype that reveals its pathogenicity. Staphylococcus sp. possesses a
variety of transmissible genes that cause them to be resistant to treatments such as antibiotics. The
discovery of antibiotics by Alexander Fleming has long been a boon in the fight against bacterial
illnesses. Drug-resistant bacteria have emerged as a result of antibiotic overuse and suboptimal usage,
attracting the attention of scientists throughout the world. Therefore, as a first step in combating
drug-resistant bacteria, it is obvious that widespread efforts to curb antibiotic abuse are required.
This review focuses on and brings to society the prevalence of different multidrug resistant genes in
Staphylococcus aureus and their transmission.
