Title:Role of Activator Protein-1 Transcription Factor in Oral Cancer
Volume: 19
Issue: 2
Author(s): S.C. Srushti, M.N. Kumar, S. Hegde, S. Biradar, S.J. Shreedevi, S.J. Prashanth and R.L. Babu*
Affiliation:
- Department of Bioinformatics and Biotechnology, Karnataka State Akkamahadevi Women’s University, Vijayapura-
586108, Karnataka, India
Keywords:
Cancer diagnosis, squamous cell oral carcinoma, OSCC, transcription factors, AP-1, malignant cells.
Abstract: Cancer is a multi-step process involving alterations in epigenetic and genetic processes.
Oral squamous cell carcinoma is a frequent oral malignancy that originates from the transformation
of normal cells into malignant cells as a consequence of failures in a series of normal molecular and
cellular processes. The mechanism of human carcinogenesis is often seen as a double-edged sword,
with the body's system being thought to counteract the detrimental consequences of neoplastic cell
proliferation while simultaneously promoting tumor development. Various transcription factors play
a significant part in cancer regulation, with the activator protein-1 family of transcription factors
(TFs) being the most prominent regulatory protein family. The Jun, Fos, ATF, and MAF protein
families are all present in the AP-1 dimeric complex. While certain AP-1 proteins, including JunB
and c-Fos, are known to be majorly oncogenic in function, experimental studies have shown that
other AP-1 proteins, such as JunB and c-Fos, also play a critical role in tumor suppression. The aim
of this review is to offer breakthrough information on the role of molecular mechanisms mediated by
AP-1 TFs in tumor development and its environment.
