Title:Protein Phosphorylation Mechanism of Mesenchymal Stem Cells in
the Treatment of Sepsis: A Systematic Review and Meta-analysis
Volume: 23
Issue: 10
Author(s): Hongwu Wang, Junlin Luo, Yong Zhong*Lian Ma*
Affiliation:
- Department of Pediatrics, The Southeast General Hospital of Dongguan, Dongguan, China
- Department of Hematology and Oncology, Shenzhen Children's Hospital of China Medical University, Shenzhen, China
- Department of Pediatrics, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China
- Department of Pediatrics, The Third Affiliated Hospital of Guangzhou Medical University (Affiliated
Women and Children's Hospital of Guangzhou Medical University), Guangzhou, Guangdong, China
Keywords:
Mesenchymal, stem cell, sepsis, protein, phosphorylation, mechanism, systemic review.
Abstract:
Background: The severity and mortality of sepsis are related to excessive
inflammation and cytokine storm. Nevertheless, little is known about why sepsis has a
significant increase in proinflammatory cytokine production, which leads to more severe
inflammatory damage.
Methods: Mesenchymal stem cells have achieved certain results in the treatment of
sepsis, but the specific mechanism remains to be further clarified.
Results: Therefore, this paper will elaborate on the currently recognized mechanism
of mesenchymal stem cells in the treatment of sepsis, the protein phosphorylation mechanism
of sepsis inflammatory response, and the possibility that mesenchymal stem
cells may block the occurrence and development of sepsis by regulating relevant
pathways or protein phosphorylation.
Conclusion: It provides a novel target for mesenchymal stem cells to prevent intervention
or therapeutically block the development of sepsis.
