Title:A Comprehensive Review on Nanomedicine: Promising Approach for
Treatment of Brain Tumor through Intranasal Administration
Volume: 24
Issue: 1
关键词:
纳米医学，脑肿瘤，血脑屏障，鼻内输送，纳米技术，CNS疾病。
摘要: Brain tumors have become one of the deadliest cancers; however, their treatment is still
limited by conventional approaches. Brain tumors, among other CNS diseases, are the most lethal
form of cancer due to ineffective diagnosis and profiling. The major limiting factor in treating brain
tumors is the blood-brain barrier (BBB), and the required therapeutic concentration is not achieved.
Hence, most drugs are prescribed at higher doses, which have several unwanted side effects. Nanotechnology
has emerged as an interesting and promising new approach for treating neurological disorders,
including brain tumors, with the potential to overcome concerns related to traditional therapeutic
approaches. Moreover, biomimetic nanomaterials have been introduced to successfully cross
the blood-brain barrier and be consumed by deep skin cancer for imaging brain tumors using multimodal
functional nanostructures for more specific and reliable medical assessment. These nanomedicines
can address several challenges by enhancing the bioavailability of therapeutics through
controlled pharmacokinetics and pharmacodynamics. Further nasal drug delivery has been considered
as an alternative approach for the brain's targeting for the treatment of several CNS diseases. A
drug can be directly delivered to the brain by bypassing the BBB through intranasal administration.
This review discusses intranasal nanomedicine-based therapies for brain tumor targeting, which can
be explored from different perspectives.
