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Research Article

DPP-Cu2+配合物门控介孔二氧化硅纳米颗粒用于pH和氧化还原双重刺激响应药物递送

卷 30, 期 28, 2023

发表于: 28 November, 2022

页: [3249 - 3260] 页: 12

弟呕挨: 10.2174/0929867329666221011110504

价格: $65

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摘要

目的：制备一种简单的 pH 和氧化还原双重刺激响应二酮吡咯并吡咯 (DPP)-Cu2 配合物门控介孔二氧化硅纳米粒子（MSN），用于精确给药和控制药物释放。 方法：采用溶胶-凝胶法制备MSN，然后层压。将羧酸 (CA)-Pyrrolo[3,4-c] pyrrole-1,4-dione, 2,5-dihydro-3,6-di-2-pyridinyl (PyDPP) 接枝到氨基功能化 MSN 的表面（MSN-NH2）通过简单的酰胺反应，然后与 Cu2 络合，在阿霉素（DOX）加载后形成门控分子。 结果：扫描电子显微镜（SEM）、透射电子显微镜（TEM）和低角X射线衍射（XRD）表明，成功制备了具有均匀粒径（100 nm）和多孔结构的MSN。制备的 MSN、MSN-NH2 和 MSN-DPP 通过 Zeta 电位、傅立叶变换红外光谱 (FTIR)、X 射线光电子能谱（XPS）和氮吸附-脱附进行了全面表征。通过优化 MSN 与 DOX 的质量比，实现了高 DOX 负载能力（18.22%）和封装效率（89.16%）。释放研究表明，我们设计的 DPP-Cu2 复合物的门控分子在生理条件下具有良好的阻断作用（药物在 24 小时内的累积释放率仅为 4.18%），并且对 pH 和氧化还原谷胱甘肽（GSH）双重反应良好刺激。体外细胞毒性试验表明，MSN-DPP-Cu2在Hep G2细胞和L02细胞中均具有良好的生物兼容性（48小时内两种细胞的相对细胞活力均在97%以上），MSN-DPP-Cu2@DOX可用于触发 Hep G2 细胞中的有效药物释放。 结论：本研究描述的MSN-DPP-Cu2可能是一种良好的抗肿瘤药物控释递送系统，为未来的临床应用提供了潜在的可能性。

关键词: 介孔二氧化硅纳米颗粒，二酮吡咯吡咯，pH响应，氧化还原响应，药物递送，控释，门控。

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