Title:Nanotechnology for Targeted Drug Delivery to Treat Osteoporosis
Volume: 24
Issue: 1
Author(s): Malkiet Kaur, Manju Nagpal*Geeta Aggarwal
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India
Keywords:
Nanotechnology, nanostructured carriers, nanomaterials, bone diseases, osteoporosis, biologics, nanotoxicity.
Abstract: Bone diseases such as rheumatoid arthritis, Paget's disease, and osteoporosis cause mortality
and mobility limits. Nanomedicine and nano delivery systems have been utilised to deliver active
drug moiety to the precisely targeted site in a controlled manner, and it serves as a means of diagnostic
tools. The utilisation of nanomedicine is expanding vigorously for assured targeting and
efficient drug delivery. Nanotechnology offers various advantages, such as site-specific targeting,
precise drug release kinetics, and improved bone mineral density. Recent medications available for
osteoporosis are not viable due to the adverse effects associated with them and low patient compliance.
There is an urgent need to develop biocompatible and appropriate drug delivery nanocarriers
such as nanoparticles, liposomes, hydrogels, dendrimers, micelles, mesoporous particles, etc. These
carriers enhance drug delivery and therapeutic effectiveness in bone tissues. The use of nanotechnology
is also associated with toxicity. This article presents the review of various reports on
nanocarrier systems and biologics for the treatment of osteoporosis. It aims to provide researchers
with a clue for inventing a new drug delivery system with site-specific targeting for the treatment of
osteoporosis.