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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Review Article

Non-Alcoholic Fatty Pancreas Disease: The Unsung Disease

Author(s): Burak C. Sevim, Harleen Chela, Hamza Ertugrul, Lyiba S. Malik, Suha Malik, Omer Basar, Ebubekir Daglilar, Sami Samiullah, Ayman H. Gaballah and Veysel Tahan*

Volume 23, Issue 4, 2023

Published on: 20 December, 2022

Page: [485 - 493] Pages: 9

DOI: 10.2174/1871530322666220929142905

Price: $65

Abstract

Non-alcoholic fatty pancreas disease (NAFPD) is a relatively new and emerging disease that is increasingly diagnosed yearly, like non-alcoholic fatty liver disease (NAFLD). It is associated especially with metabolic syndrome and obesity. As awareness of pancreatic steatosis and its clinical implications increase, it is diagnosed more frequently. The researchers have explained the clinical importance of NAFPD and the diseases it causes, such as pancreatitis, pancreatic insufficiency, and pancreatic cancer. Although the definitive treatment is not yet established, the primary treatment approach is weight loss since NAFPD is associated with metabolic syndrome as well as obesity. Although pharmacological agents, such as oral hypoglycemic agents, have been investigated in animal experiments, studies on humans have not been conducted. Since the research on NAFPD is still insufficient, it is a subject that needs to be investigated, and further studies are needed to explore its pathophysiology, clinical impact, and its management.

Keywords: Pancreatic cancer, fatty, pancreas, NAFPD, steatopancreatitis, obesity, non-alcoholic fatty liver disease.

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Graphical Abstract

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