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Mini-Review Article

Epileptic Targets and Drugs: A Mini-Review

Author(s): Teresa Carolliny Moreira Lustoza Rodrigues, Jéssica Paiva de Moura, Aline Matilde Ferreira dos Santos, Alex France M. Monteiro, Simone Mendes Lopes, Marcus Tullius Scotti and Luciana Scotti*

Volume 24, Issue 3, 2023

Published on: 27 October, 2022

Page: [212 - 224] Pages: 13

DOI: 10.2174/1389450123666220927103715

Price: $65

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Abstract

Background: Epilepsy is a neurological disease affected by an imbalance of inhibitory and excitatory signaling in the brain.

Introduction: In this disease, the targets are active in pathophysiology and thus can be used as a focus for pharmacological treatment.

Methods: Several studies demonstrated the antiepileptic effect of drugs acting on the following targets: N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, voltage-gated calcium channel (Cav), Gamma aminobutyric acid transporter type 1 (GAT1), voltage-gated sodium channels (Nav), voltage-gated potassium channel of the Q subfamily (KCNQ) and Gamma aminobutyric acid type A (GABAA) receiver.

Results: These studies highlight the importance of molecular docking.

Conclusion: Quantitative Structure-Activity Relationship (QSAR) and computer aided drug design (CADD) in predicting of possible pharmacological activities of these targets.

Keywords: Molecular docking, AMPA, NMDA, GAT1, KCNQ, Cav, Nav e GABAA.

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