Title:Study on Multi-Target Synergistic Treatment of Alzheimer’s Disease
Based on Metal Chelators
Volume: 24
Issue: 2
关键词:
多靶点,阿尔茨海默病,金属稳态,金属螯合剂,协同治疗,氧化应激
摘要: Alzheimer's disease (AD) has become the fourth leading cause of death in the world. Due
to its complex pathogenesis, there is still a lack of effective drug treatments. Studies have found that
the metal dyshomeostasis is closely related to other pathogeneses of AD such as oxidative stress,
β-amyloid protein deposits, etc. Therefore, it becomes an important target to find the appropriate
metal chelating agents to regulate the metal homeostasis. At the same time, because of the complex
pathogenesis, single target drugs cannot achieve good effects. Therefore, current studies are mainly
focused on exploring multi-target therapy for AD. In this work, the multi-target studies based on
metal chelators and other targets with synergistic anti-AD activities were reviewed. The structural
characteristics of different chelating agents were summarized and the structure-activity relationship
was analyzed, which provided some valuable clues for the subsequent development of anti-AD
multi-target drugs based on metal chelating agents.