Title:Gastrointestinal System: COVID-19 and Potential Mechanisms Associated
with Coagulopathy
Volume: 23
Issue: 17
关键词:
2019冠状病毒病，SARS-CoV-2，高凝状态，血栓栓塞，炎症性肠病，慢性肝病，腹腔疾病
摘要: SARS-CoV-2 is a novel coronavirus that expanded worldwide, generating a pandemic of
acute respiratory syndrome called “coronavirus disease 2019” (COVID-19), which resulted in a
global health crisis. The spectrum of COVID-19 manifestations ranges from none or mild symptoms
to severe respiratory failure associated with systemic manifestations, mostly gastrointestinal
symptoms. Hypercoagulability is an important feature of COVID-19 disease, which can potentially
influence patients’ prognosis. Therefore, gastroenterologists should focus on subjects with concomitant
hypercoagulable gastrointestinal disorders as they may display a higher risk of thrombotic
complications during SARS-CoV-2 infection. The aim of this review is to summarize the available
evidence regarding the interplay of the prothrombotic pathogenetic mechanisms of both COVID-19
and hypercoagulable digestive diseases and the possible clinical implications. We summarized the
potential interplay of prothrombotic mechanisms of both COVID-19 and hypercoagulable digestive
diseases in the graphical abstract.
