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Review Article

A Review of the Medicinal Uses, Phytochemistry and Pharmacology of Genus Flueggea

Author(s): Yi-ling Peng, Ni Zeng, Qing-ying Yao, Cai-yun Peng, Wen-bing Sheng*, Bin Li* and Wei Wang

Volume 3, Issue 3, 2023

Published on: 13 October, 2022

Page: [213 - 241] Pages: 29

DOI: 10.2174/2210298102666220920110106

Open Access Journals Promotions 2
Abstract

The genus Flueggea Willd. belongs to the Euphorbiaceae family and is widely distributed in Asia, South America, Oceania, and Europe, with sixteen species. Several species, such as Flueggea suffruticosa and Flueggea virosa, have been used as traditional medicines in Southeast Asia and Africa for a long time for their good medicinal effects in treating rheumatoid arthritis, traumatic injury, gastrointestinal disease etc. The characteristic chemical constituents of this genus are alkaloids and diterpenoids, which show antiviral, anti-inflammatory, analgesic, antitumor, antibacterial, antioxidant, and neuroprotective activities. This review summarizes the traditional medicinal values, chemical constituents, and pharmacological activities of the genus Flueggea to provide a useful reference for the follow-up research and application of the genus.

Keywords: Flueggea Willd., chemical constituents, alkaloids, diterpenoids, antitumor, anti-inflammatory, antiviral.

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[1]
Chao, C.H.; Cheng, J.C.; Shen, D.Y.; Huang, H.C.; Wu, Y.C.; Wu, T.S. Terpenoids from Flueggea virosa and their anti-hepatitis C virus activity. Phytochemistry, 2016, 128, 60-70.
[http://dx.doi.org/10.1016/j.phytochem.2016.04.003] [PMID: 27112277]
[2]
Editorial Committee of Flora of China, Chinese Academy of Sciences. Flora of China; Science Press: Beijing, China, 1994, 44, p. (1)68. Available from: https://www.worldcat.org/title/flora-of-china/oclc/31225309
[3]
Wang, X.F.; Liu, F.F.; Zhu, Z.; Fang, Q.Q.; Qu, S.J.; Zhu, W.; Yang, L.; Zuo, J.P.; Tan, C.H.; Flueggenoids, A.; Flueggenoids, A. E, new dinorditerpenoids from Flueggea virosa. Fitoterapia, 2019, 133, 96-101.
[http://dx.doi.org/10.1016/j.fitote.2018.12.025] [PMID: 30605781]
[4]
Wu, Z.L.; Zhao, B.X.; Huang, X.J.; Tang, G.Y.; Shi, L.; Jiang, R.W.; Liu, X.; Wang, Y.; Ye, W.C. Suffrutines A and B: A pair of Z/E isomeric indolizidine alkaloids from the roots of Flueggea suffruticosa. Angew. Chem. Int. Ed., 2014, 53(23), 5796-5799.
[http://dx.doi.org/10.1002/anie.201400048] [PMID: 24729281]
[5]
Qin, S.; Liang, J.Y.; Gu, Y.C.; Guo, Y.W. Suffruticosine, a novel octacyclic alkaloid with an unprecedented skeleton from Securinega suffruticosa (Pall.). Rehd. Tetrahedron Lett., 2008, 49(49), 7066-7069.
[http://dx.doi.org/10.1016/j.tetlet.2008.09.148]
[6]
Park, K.J.; Kim, C.S.; Khan, Z.; Oh, J.; Kim, S.Y.; Choi, S.U.; Lee, K.R. Securinega alkaloids from the twigs of Securinega suffruticosa and their biological activities. J. Nat. Prod., 2019, 82(5), 1345-1353.
[http://dx.doi.org/10.1021/acs.jnatprod.9b00142] [PMID: 31082231]
[7]
Yang, X.; Liu, J.; Huo, Z.; Yuwen, H.; Li, Y.; Zhang, Y. Fluevirines E and F, two new alkaloids from Flueggea virosa. Nat. Prod. Res., 2020, 34(14), 2001-2006.
[http://dx.doi.org/10.1080/14786419.2019.1569661] [PMID: 30721084]
[8]
Gan, L.S.; Fan, C.Q.; Yang, S.P.; Wu, Y.; Lin, L.P.; Ding, J.; Yue, J.M. Flueggenines A and B, two novel C,C-linked dimeric indolizidine alkaloids from Flueggea virosa. Org. Lett., 2006, 8(11), 2285-2288.
[http://dx.doi.org/10.1021/ol060551f] [PMID: 16706507]
[9]
Xie, Q.J.; Zhang, W.Y.; Wu, Z.L.; Xu, M.T.; He, Q.F.; Huang, X.J.; Che, C.T.; Wang, Y.; Ye, W.C. Alkaloid constituents from the fruits of Flueggea virosa. Chin. J. Nat. Med., 2020, 18(5), 385-392.
[http://dx.doi.org/10.1016/S1875-5364(20)30045-5] [PMID: 32451096]
[10]
Thrikawala, V.S.; Deraniyagala, S.A.; Dilanka, F.C.; Udukala, D.N. In vitro α-amylase and protein glycation inhibitory activity of the aqueous extract of flueggea leucopyrus willd. J. Chem., 2018, 2018(3), 2787138.
[http://dx.doi.org/10.1155/2018/2787138]
[11]
Soysa, P.; De Silva, I.S.; Wijayabandara, J. Evaluation of antioxidant and antiproliferative activity of Flueggea leucopyrus Willd (katupila). BMC Complement. Altern. Med., 2014, 14(1), 274.
[http://dx.doi.org/10.1186/1472-6882-14-274] [PMID: 25074702]
[12]
Vasantrao, U.S.; Biyani, K.R. Evaluation of preclinical aphrodisiac activity of Flueggea leucopyrus Willd. leaves. Curr. Bioact. Compd., 2020, 16(3), 335-341.
[http://dx.doi.org/10.2174/1573407214666181105115510]
[13]
Huang, D.; Luo, X.; Yin, Z.; Xu, J.; Gu, Q. Diterpenoids from the aerial parts of Flueggea acicularis and their activity against RANKL-induced osteoclastogenesis. Bioorg. Chem., 2020, 94, 103453.
[http://dx.doi.org/10.1016/j.bioorg.2019.103453] [PMID: 31787342]
[14]
Gemici, M.; Demiray, H.; Yildirim, H. Antibacterial and antifungal activities of Flueggea anatolica (Euphorbiaceae). Asian J. Chem., 2010, 22(5), 3802-3806.
[http://dx.doi.org/10.1042/0264-6021:3410647]
[15]
Zhou, L.; Zhao, B.X.; Jiang, R.W.; Huang, X.J.; Wu, Z.L.; Wang, Y.; Ye, W.C. Securinega alkaloids from the fruits of Flueggea suffruticosa. J. Asian Nat. Prod. Res., 2014, 16(6), 593-601.
[http://dx.doi.org/10.1080/10286020.2014.930443] [PMID: 24957326]
[16]
Wang, Y.; Li, Q.; Ye, W.C.; IP, F.; IP, N.; Zhao, S.X. Chemical consitituents of Securinega suffruticosa. Chin. J. Nat. Med., 2006, 4(04), 260-263.
[17]
Wu, Z.L.; Huang, X.J.; Xu, M.T.; Ma, X.; Li, L.; Shi, L.; Wang, W.J.; Jiang, R.W.; Ye, W.C.; Wang, Y. Flueggeacosines A–C, dimeric securinine-type alkaloid analogues with neuronal differentiation activity from Flueggea suffruticosa. Org. Lett., 2018, 20(23), 7703-7707.
[http://dx.doi.org/10.1021/acs.orglett.8b03432] [PMID: 30484660]
[18]
Kurbanov, U.K.; Tashkhodjaev, B.; Levkovich, M.G.; Bruskov, V.P.; Mukarramov, N.I.; Abdullaev, N.D. Main alkaloids of securinega suffruticosa. Nitrogen atom inversion in securinine. J. Struct. Chem., 2019, 60(9), 1489-1495.
[http://dx.doi.org/10.1134/S0022476619090142]
[19]
Ohsaki, A.; Kobayashi, Y.; Yoneda, K.; Kishida, A.; Ishiyama, H. Securinega alkaloids from the wood of Securinega suffruticosa var. amamiensis. J. Nat. Prod., 2007, 70(12), 2003-2005.
[http://dx.doi.org/10.1021/np0780102] [PMID: 18052029]
[20]
Ohsaki, A.; Ishiyama, H.; Yoneda, K.; Kobayashi, J. Secu’amamine A, a novel indolizidine alkaloid from Securinega suffruticosa var. amamiensis. Tetrahedron Lett., 2003, 44(15), 3097-3099.
[http://dx.doi.org/10.1016/S0040-4039(03)00546-X]
[21]
Gan, L.S.; Yue, J.M. Alkaloids from the root of Flueggea Virosa. Nat. Prod. Commun., 2006, 1(10), 819-823.
[http://dx.doi.org/10.1177/1934578X0600101002]
[22]
Zhang, D.B.; Song, Z.X.; Tang, Z.S. Studies on alkaloids from the leaves of Flueggea virosa and their acetylcholinesterase inhibitory activities. Zhong Yao Cai, 2018, 41(01), 99-102.
[23]
Al-Rehaily, A.J.; Yousaf, M.; Ahmad, M.S.; Samoylenko, V.; Li, X.C.; Muhammad, I.; El Tahir, K.E.H. Chemical and biological study of Flueggea virosa native to Saudi Arabia. Chem. Nat. Compd., 2015, 51(1), 187-188.
[http://dx.doi.org/10.1007/s10600-015-1240-9]
[24]
Liang, J.P.; Wang, G.C.; Wang, Y. Study on the alkaloid components of Flueggea leucopyrus. Chin. Tradit. Herbal Drugs, 2010, 41(07), 1072-1075.
[25]
Ji, Y.J.; Wen, C.Q.; Chen, A.H.; Qiao, L.F.; Li, X.B.; Liu, Y.P. Studies on the chemical constituents from stems and leaves of Flueggea Virosa (II). Guangdong Huagong, 2015, 42(08), 67-68.
[26]
Ohsaki, A.; Nagaoka, T.; Yoneda, K.; Kishida, A. Secu’amamines E–G, new alkaloids from Securinega suffruticosa var. amamiensis. Tetrahedron Lett., 2009, 50(50), 6965-6967.
[http://dx.doi.org/10.1016/j.tetlet.2009.09.138]
[27]
Qin, S.; Liang, J.Y.; Guo, Y.W. Two new Securinega alkaloids from Securinega suffruticosa. Helv. Chim. Acta, 2009, 92(2), 399-403.
[http://dx.doi.org/10.1002/hlca.200800263]
[28]
Xie, Q.J. Study on alkaloids of the twigs and leaves of Flueggea suffruticosa. Master Thesis, Jinan University, Guangzhou, 2019.
[29]
Wang, G.; Wang, Y.; Zhang, X.; Li, Y.; Yao, X.; Ye, W. Securinega alkaloids from Flueggea leucopyra. Chem. Pharm. Bull., 2010, 58(3), 390-393.
[http://dx.doi.org/10.1248/cpb.58.390] [PMID: 20190447]
[30]
Yang, X. Investigation on the structure and activity of alkaloids in Flueggea virosa. Master Thesis, Guizhou University, Guizhou, 2019.
[31]
Wang, G.Y. Alkaloids from the twigs and leaves of Flueggea suffruticosa. Master Thesis, Jinan University, Guangzhou, 2016.
[32]
Wu, H.Y.; Zhou, J.Y. [Studies on chemical constituents from leaves of Securinega suffruticosa.]. Zhongguo Zhongyao Zazhi, 2004, 29(6), 535-537.
[PMID: 15706917]
[33]
Studies on chemical constituents of the leaves of Securinega suffruticosa (Pall.) Rehd; Master Thesis, Jilin University: Changchun, 2010.
[34]
Luo, X.K.; Cai, J.; Yin, Z.Y.; Luo, P.; Li, C.J.; Ma, H.; Seeram, N.P.; Gu, Q.; Xu, J. Fluvirosaones A and B, two indolizidine alkaloids with a pentacyclic skeleton from Flueggea virosa. Org. Lett., 2018, 20(4), 991-994.
[http://dx.doi.org/10.1021/acs.orglett.7b03935] [PMID: 29364678]
[35]
Wang, G.C.; Liang, J.P.; Wang, Y.; Li, Q.; Ye, W.C. Chemical constituents from Flueggea virosa. Zhongguo Tianran Yaowu, 2008, 6(04), 251-253.
[36]
Wang, G.C.; Wang, Y.; Li, Q.; Liang, J.P.; Zhang, X.Q.; Yao, X.S.; Ye, W.C. Two new alkaloids from Flueggea virosa. Helv. Chim. Acta, 2008, 91(6), 1124-1129.
[http://dx.doi.org/10.1002/hlca.200890120]
[37]
Tatematsu, H.; Mori, M.; Yang, T.H.; Chang, J.J.; Lee, T.T.Y.; Lee, K.H. Cytotoxic principles of Securinega virosa: Virosecurinine and viroallosecurinine and related derivatives. J. Pharm. Sci., 1991, 80(4), 325-327.
[http://dx.doi.org/10.1002/jps.2600800408] [PMID: 1865332]
[38]
Wang, A.T. Alkaloids from the fruits of Flueggea virosa. Master Thesis, Jinan University, Guangzhou, 2016.
[39]
Zhang, D.B. Studies on the structures and bioactivities of alkaloids from four medical plants. Master Thesis, Lanzhou University, Lanzhou, 2015.
[40]
Li, X.H.; Cao, M.M.; Zhang, Y.; Li, S.L.; Di, Y.T.; Hao, X.J. Fluevirines A–D, four new securinega-type alkaloids from Flueggea virosa. Tetrahedron Lett., 2014, 55(44), 6101-6104.
[http://dx.doi.org/10.1016/j.tetlet.2014.09.046]
[41]
Xu, M.T. Alkaloids from the fruits of Flueggea virosa. Master Thesis, Jinan University, Guangzhou, 2018.
[42]
Iketubosin, G.O.; Mathieson, D.W. The isolation of hordenine and norsecurinine from Securinega virosa (Baill.). The structure of norsecurinine. J. Pharm. Pharmacol., 2011, 15(1), 810-815.
[http://dx.doi.org/10.1111/j.2042-7158.1963.tb12885.x] [PMID: 14134116]
[43]
Zhang, H.; Zhu, K.K.; Han, Y.S.; Luo, C.; Wainberg, M.A.; Yue, J.M. Flueggether A and virosinine A, anti-HIV alkaloids from Flueggea virosa. Org. Lett., 2015, 17(24), 6274-6277.
[http://dx.doi.org/10.1021/acs.orglett.5b03320] [PMID: 26632657]
[44]
Zhang, H.; Zhang, C.R.; Han, Y.S.; Wainberg, M.A.; Yue, J.M. New Securinega alkaloids with anti-HIV activity from Flueggea virosa. RSC Advances, 2015, 5(129), 107045-107053.
[http://dx.doi.org/10.1039/C5RA22191A]
[45]
Zhao, B.X.; Wang, Y.; Zhang, D.M.; Huang, X.J.; Bai, L.L.; Yan, Y.; Chen, J.M.; Lu, T.B.; Wang, Y.T.; Zhang, Q.W.; Ye, W.C. Virosaines A and B, two new birdcage-shaped Securinega alkaloids with an unprecedented skeleton from Flueggea virosa. Org. Lett., 2012, 14(12), 3096-3099.
[http://dx.doi.org/10.1021/ol301184j] [PMID: 22650148]
[46]
Saito, S.; Tanaka, T.; Kotera, K.; Nakai, H.; Sugimoto, N.; Horii, Z.; Ikeda, M.; Tamura, Y. Structures of norsecurinine and dihydronorsecurinine. Chem. Pharm. Bull. (Tokyo), 1965, 13(7), 786-796.
[http://dx.doi.org/10.1248/cpb.13.786] [PMID: 5867805]
[47]
Dehmlow, E.V.; Guntenhöner, M.; Van Ree, T. A novel alkaloid from Fluggea virosa: 14,15-epoxynorsecurinine. Phytochemistry, 1999, 52(8), 1715-1716.
[http://dx.doi.org/10.1016/S0031-9422(99)00208-3]
[48]
Zhao, J.H.; Peng, B.; Pu, H.L. Studies on chemical constituents from the aerial parts of Fluggea virosa. Symposium on Sustainable Development of Medicinal Plant Chemistry and Traditional Chinese Medicine Resources, Xining2009.
[49]
Chen, M.J.; Hou, L.L. Study on the chemical constituents of Fluggea virosa (Roxb. ex willd.). Baill. J. Integr. Plant Biol., 1985, 27(06), 625-629.
[50]
Li, W.Y. Studies on the chemical constituents of Flueggea virosa. Master Thesis, Yunnan Normal University, Kunming, 2021.
[51]
Zhang, H.; Zhu, K.K.; Gao, X.H.; Yue, J.M. Natural occurrence of all eight stereoisomers of a neosecurinane structure from Flueggea virosa. Tetrahedron, 2017, 73(31), 4692-4697.
[http://dx.doi.org/10.1016/j.tet.2017.06.035]
[52]
Wu, Z.L.; Huang, X.J.; Hu, L.J.; Zhang, W.Y.; Xie, Q.J.; Jiang, R.W.; Wang, Y.; Ye, W.C. Absolute configurations and stereochemical inversion mechanism of epimeric Securinega alkaloids from Flueggea suffruticosa. Org. Lett., 2020, 22(9), 3673-3678.
[http://dx.doi.org/10.1021/acs.orglett.0c01167] [PMID: 32319780]
[53]
Wang, Y.; Li, Q.; Ye, W.C.; IP, F.; IP, N.; Zhao, S.X. Alkaloids from Securinega suffruticosa. Zhongcaoyao, 2007, 38(02), 163-167.
[54]
He, Q.F.; Wu, Z.L.; Li, L.; Sun, W.Y.; Wang, G.Y.; Jiang, R.W.; Hu, L.J.; Shi, L.; He, R.R.; Wang, Y.; Ye, W.C. Discovery of neuritogenic Securinega alkaloids from Flueggea suffruticosa by a building blocks-based molecular network strategy. Angew. Chem. Int. Ed., 2021, 60(36), 19609-19613.
[http://dx.doi.org/10.1002/anie.202103878] [PMID: 34196083]
[55]
Zhao, B.X.; Wang, Y.; Li, C.; Wang, G.C.; Huang, X.J.; Fan, C.L.; Li, Q.M.; Zhu, H.J.; Chen, W.M.; Ye, W.C. Flueggedine, a novel axisymmetric indolizidine alkaloid dimer from Flueggea virosa. Tetrahedron Lett., 2013, 54(35), 4708-4711.
[http://dx.doi.org/10.1016/j.tetlet.2013.06.097]
[56]
Zhao, B.X.; Wang, Y.; Zhang, D.M.; Jiang, R.W.; Wang, G.C.; Shi, J.M.; Huang, X.J.; Chen, W.M.; Che, C.T.; Ye, W.C. Flueggines A and B, two new dimeric indolizidine alkaloids from Flueggea virosa. Org. Lett., 2011, 13(15), 3888-3891.
[http://dx.doi.org/10.1021/ol201410z] [PMID: 21728296]
[57]
Zhang, H.; Wei, W.; Yue, J.M. From monomer to tetramer and beyond: The intriguing chemistry of Securinega alkaloids from Flueggea virosa. Tetrahedron, 2013, 69(19), 3942-3946.
[http://dx.doi.org/10.1016/j.tet.2013.03.028]
[58]
Zhang, H.; Han, Y.S.; Wainberg, M.A.; Yue, J.M. Flueggethers B–D, Securinega alkaloids with rare oligomerizing pattern from Flueggea virosa. Tetrahedron Lett., 2016, 57(16), 1798-1800.
[http://dx.doi.org/10.1016/j.tetlet.2016.03.034]
[59]
Wang, G.Y.; Wang, A.T.; Zhao, B.X.; Lei, X.P.; Zhang, D.M.; Jiang, R.W.; Wang, Y.; Ye, W.C. Norsecurinamines A and B, two norsecurinine-derived alkaloid dimers from the fruits of Flueggea virosa. Tetrahedron Lett., 2016, 57(34), 3810-3813.
[http://dx.doi.org/10.1016/j.tetlet.2016.06.113]
[60]
Zhang, H.; Zhang, C.R.; Zhu, K.K.; Gao, A.H.; Luo, C.; Li, J.; Yue, J.M. Fluevirosines A-C: A biogenesis inspired example in the discovery of new bioactive scaffolds from Flueggea virosa. Org. Lett., 2013, 15(1), 120-123.
[http://dx.doi.org/10.1021/ol303146a] [PMID: 23244193]
[61]
Zhang, H.; Han, Y.S.; Wainberg, M.A.; Yue, J.M. Anti-HIV Securinega alkaloid oligomers from Flueggea virosa. Tetrahedron, 2015, 71(22), 3671-3679.
[http://dx.doi.org/10.1016/j.tet.2014.10.064]
[62]
Chao, C.H.; Cheng, J.C.; Shen, D.Y.; Wu, T.S. Anti-hepatitis C virus dinorditerpenes from the roots of Flueggea virosa. J. Nat. Prod., 2014, 77(1), 22-28.
[http://dx.doi.org/10.1021/np400528h] [PMID: 24400834]
[63]
Yuan, W.; Lu, Z.; Liu, Y.; Meng, C.; Cheng, K.; Zhu, P. Three new podocarpane-type diterpenoids from callus of Securinega suffruticosa. Chem. Pharm. Bull., 2005, 53(12), 1610-1612.
[http://dx.doi.org/10.1248/cpb.53.1610] [PMID: 16327202]
[64]
Chao, C.H.; Cheng, J.C.; Shen, D.Y.; Huang, H.C.; Wu, Y.C.; Wu, T.S. 13-Methyl-3,4-seco-ent-podocarpanes, rare C18-diterpenoids from the roots of Flueggea virosa. RSC Advances, 2016, 6(41), 34708-34714.
[http://dx.doi.org/10.1039/C6RA00843G]
[65]
Chao, C.H.; Lin, Y.J.; Cheng, J.C.; Huang, H.C.; Yeh, Y.J.; Wu, T.S.; Hwang, S.Y.; Wu, Y.C. Chemical constituents from Flueggea virosa and the structural revision of dehydrochebulic acid trimethyl ester. Molecules, 2016, 21(9), 1239-1246.
[http://dx.doi.org/10.3390/molecules21091239] [PMID: 27649134]
[66]
Chao, C.H.; Cheng, J.C.; Hwang, T.L.; Shen, D.Y.; Wu, T.S. Trinorditerpenes from the roots of Flueggea virosa. Bioorg. Med. Chem. Lett., 2014, 24(2), 447-449.
[http://dx.doi.org/10.1016/j.bmcl.2013.12.051] [PMID: 24388689]
[67]
Liu, Y.P.; Chen, A.H.; Qiao, L.F.; Wen, C.Q.; Xu, X.Y.; Fu, Y.H. Studies on the chemical constituents from stems and leaves of Flueggea virosa. Guangdong Huagong, 2015, 42(05), 12-13.
[68]
Monkodkaew, S.; Loetchutin, C.; Nuntasaen, N.; Pompimon, W. Identification and antiproliferative activity evaluation of a series of triterpenoids isolated from Flueggea virosa (Roxb. ex Willd.). Am. J. Appl. Sci., 2009, 6(10), 1800-1806.
[http://dx.doi.org/10.3844/ajassp.2009.1800.1806]
[69]
Sun, L. Study on chemical constituents and antioxidation activity of Securinega suffruticosa (Pall.) Reha. Master Thesis, Yanbian University: Yanji, 2012.
[70]
Sanogo, R.; Vassallo, A.; Malafronte, N.; Imparato, S.; Russo, A.; Piaz, F.D. New phenolic glycosides from Securinega virosa and their antioxidant activity. Nat. Prod. Commun., 2009, 4(12), 1645-1650.
[http://dx.doi.org/10.1177/1934578X0900401207] [PMID: 20120099]
[71]
Aleshkina, I.A.; Turova, A.D. Pharmacology of a new alkaloid securinine. Farmakol. Toksikol., 1956, 19(4), 11-17.
[PMID: 13375695]
[72]
Beutler, J.A.; Karbon, E.W.; Brubaker, A.N.; Malik, R.; Curtis, D.R.; Enna, S.J. Securinine alkaloids: A new class of GABA receptor antagonist. Brain Res., 1985, 330(1), 135-140.
[http://dx.doi.org/10.1016/0006-8993(85)90014-9] [PMID: 2985189]
[73]
Jia, H.Y.; Peng, J.Z.; Jiang, Z.R. Cardiovascular effects and central mechanism of L-securinine in rats. Ningxia Yixue Zazhi, 2008, (06), 487-489.
[74]
Leonoudakis, D.; Rane, A.; Angeli, S.; Lithgow, G.J.; Andersen, J.K.; Chinta, S.J. Anti-inflammatory and neuroprotective role of natural product securinine in activated glial cells: implications for Parkinson’s disease. Mediators Inflamm., 2017, 2017, 8302636.
[http://dx.doi.org/10.1155/2017/8302636] [PMID: 28473732]
[75]
Chen, Y.C.; Chang, J.G.; Liu, T.Y.; Jong, Y.J.; Cheng, W.L.; Yuo, C.Y. Securinine enhances SMN2 exon 7 inclusion in spinal muscular atrophy cells. Biomed. Pharmacother., 2017, 88, 708-714.
[http://dx.doi.org/10.1016/j.biopha.2017.01.104] [PMID: 28152480]
[76]
Xu, L.; Zhang, J.T. Effect and mechanism of securinine on synaptic transmission in the dentate gyrus of anesthetized rats. Yao Xue Xue Bao, 2001, 36(8), 565-568.
[PMID: 12579930]
[77]
Xu, L. Effect of (+)-securinine and its mechanism of action on improving learning and memory and synaptic transmission. Master Thesis, Chinese Academy of Medical Sciences & Peking Union Medical College: Beijing, 2004.
[78]
Liu, W.J.; Gu, Z.L.; Zhou, W.X.; Kwok, C.Y. Anti-tumor effect of securinine and its resistance to toxicity of cyclophosphamide. Zhongguo Yaolixue Tongbao, 1997, 13(06), 529-532.
[79]
Liu, W.J.; Gu, Z.L.; Zhou, W.X.; Guo, C.Y. Securinine induced apoptosis in K562 cells. Zhongguo Yaolixue Tongbao, 1999, 15(02), 135-138.
[80]
Li, M.; Han, S.; Zhang, G.; Wang, Y.; Ji, Z. Antiproliferative activity and apoptosis-inducing mechanism of L-securinine on human breast cancer MCF-7 cells. Pharmazie, 2014, 69(3), 217-223.
[http://dx.doi.org/10.1691/ph.2014.3802] [PMID: 24716413]
[81]
Han, S.; Yang, X.; Pan, Y.; Qi, Q.; Shen, J.; Fang, H.; Ji, Z. L-securinine inhibits the proliferation of A549 lung cancer cells and promotes DKK1 promoter methylation. Oncol. Lett., 2017, 14(4), 4243-4248.
[http://dx.doi.org/10.3892/ol.2017.6693] [PMID: 28943934]
[82]
Zhang, G.; Chen, D.Y.; Cheng, J.; Ji, Z.N. L-securinine induced the human non small cell lung cancer A549 cell autophagy and its molecular mechanism. Zhongguo Linchuang Yaolixue Yu Zhiliaoxue, 2014, 19(08), 851-855.
[83]
Han, S.; Zhang, G.; Li, M.; Chen, D.; Wang, Y.; Ye, W.; Ji, Z. L-securinine induces apoptosis in the human promyelocytic leukemia cell line HL-60 and influences the expression of genes involved in the PI3K/AKT/mTOR signaling pathway. Oncol. Rep., 2014, 31(5), 2245-2251.
[http://dx.doi.org/10.3892/or.2014.3101] [PMID: 24676995]
[84]
Zhang, J.; Yao, J.; Peng, S.; Li, X.; Fang, J. Securinine disturbs redox homeostasis and elicits oxidative stress-mediated apoptosis via targeting thioredoxin reductase. Biochim. Biophys. Acta Mol. Basis Dis., 2017, 1863(1), 129-138.
[http://dx.doi.org/10.1016/j.bbadis.2016.10.019] [PMID: 27777067]
[85]
Zhang, D.; Liu, H.; Yang, B.; Hu, J.; Cheng, Y. L-securinine inhibits cell growth and metastasis of human androgen-independent prostate cancer DU145 cells via regulating mitochondrial and AGTR1/MEK/ERK/STAT3/PAX2 apoptotic pathways. Biosci. Rep., 2019, 39(5), BSR20190469.
[http://dx.doi.org/10.1042/BSR20190469] [PMID: 30975734]
[86]
Hou, J.W. Securinine inhibits phosphorylation of STAT3 and growth of STAT3-dependent. Master Thesis, Lanzhou University: Lanzhou, 2014.
[87]
Xia, Y.; Cheng, C.; Yao, S.; Zhang, Q.; Wang, Y.; Ji, Z. l-Securinine induced the human colon cancer SW480 cell autophagy and its molecular mechanism. Fitoterapia, 2011, 82(8), 1258-1264.
[http://dx.doi.org/10.1016/j.fitote.2011.08.015] [PMID: 21907765]
[88]
Zhang, G.; Gao, X.; Zeng, H.; Li, Y.; Guo, X. Virosecurinine induces apoptosis in human leukemia THP-1 cells and other underlying molecular mechanisms. Oncol. Lett., 2017, 15(1), 849-854.
[http://dx.doi.org/10.3892/ol.2017.7437] [PMID: 29399150]
[89]
Chen, C.R.; Xia, Y.H.; Yao, S.Y.; Zhang, Q.; Wang, Y.; Ji, Z.N. Virosecurinine induces apoptosis by affecting Bcl-2 and Bax expression in human colon cancer SW480 cells. Pharmazie, 2012, 67(4), 351-354.
[http://dx.doi.org/10.1691/ph.2012.1634] [PMID: 22570942]
[90]
Zhang, G.; Li, M.; Han, S.; Chen, D.; Wang, Y.; Ye, W.; Ji, Z. Induction of human chronic myeloid leukemia K562 cell apoptosis by virosecurinine and its molecular mechanism. Mol. Med. Rep., 2014, 10(5), 2365-2371.
[http://dx.doi.org/10.3892/mmr.2014.2531] [PMID: 25189629]
[91]
Li, P.J.; Shen, W.Z.; Ye, W.C.; Su, X.P.; Sun, Y. Effect of virosecurinine on proliferation and cell cycle of mouse melanoma cell line B16. Jinan Daxue Xuebao, 2011, 32(02), 151-154.
[92]
Samarakoon, S.R.; Kotigala, S.B.; Gammana, L.I.; Thabrew, I.; Tennekoon, K.H.; Siriwardana, A.; Galhena, P.B. Cytotoxic and apoptotic effect of the decoction of the aerial parts of Flueggea leucopyrus on human endometrial carcinoma (AN3CA) cells. Trop. J. Pharm. Res., 2014, 13(6), 873-880.
[http://dx.doi.org/10.4314/tjpr.v13i6.7]
[93]
Mendis, A.S.; Thabrew, I.; Samarakoon, S.R.; Tennekoon, K.H. Modulation of expression of heat shock proteins and apoptosis by Flueggea leucopyrus (Willd) decoction in three breast cancer phenotypes. BMC Complement. Altern. Med., 2015, 15(1), 404.
[http://dx.doi.org/10.1186/s12906-015-0927-6] [PMID: 26553005]
[94]
Hettihewa, L.M.; Munasinghe, M.; Bulugahapitiya, V.B. Dose dependent anti proliferative and cytotoxic effects of Flueggea leucopyrus Willd. against human ovarian carcinoma; MTS and human telomerase enzyme inhibition. Eur. J. Biomed., 2015, 2(7), 14-18.
[95]
Han, B.H.; Song, C.H.; Yoon, J.J.; Kim, H.Y.; Seo, C.S.; Kang, D.G.; Lee, Y.J.; Lee, H.S. Anti-vascular inflammatory effect of ethanol extract from Securinega suffruticosa in human umbilical vein endothelial cells. Nutrients, 2020, 12(11), 3448.
[http://dx.doi.org/10.3390/nu12113448] [PMID: 33182831]
[96]
Liang, Y.F.; Zhou, Y.W. Study on the anti-inflammatory and analgesic effects of Flueggea virosa extract. Inter. Med., 2015, 10(06), 845-847.
[97]
Anarado, C.E.; Anarado, C.J.O.; Umedum, N.L.; Chukwubueze, F.M.; Anarado, I.L. Phytochemical and antimicrobial analysis of leaves of Bridelia micrantha, Cassytha filiformis, Euphorbia hirta and Securinega virosa. J. Pharmacogn. Phytochem., 2020, 9(3), 581-587.
[98]
Pu, H.L.; Huang, X.; Zhao, J.H.; Hong, A. Bergenin is the antiarrhythmic principle of Fluggea virosa. Planta Med., 2002, 68(4), 372-374.
[http://dx.doi.org/10.1055/s-2002-26758] [PMID: 11988869]
[99]
Lee, Y.J.; Han, B.H.; Yoon, J.J.; Kim, H.Y.; Ahn, Y.M.; Hong, M.H.; Son, C.O.; Kang, D.G.; Lee, H.S. Identification of securinine as vascular protective agent targeting atherosclerosis in vascular endothelial cells, smooth muscle cells, and apolipoprotein E deficient mice. Phytomedicine, 2021, 81(2), 153430.
[http://dx.doi.org/10.1016/j.phymed.2020.153430] [PMID: 33341451]
[100]
Singh, S.V.; Manhas, A.; Kumar, Y.; Mishra, S.; Shanker, K.; Khan, F.; Srivastava, K.; Pal, A. Antimalarial activity and safety assessment of Flueggea virosa leaves and its major constituent with special emphasis on their mode of action. Biomed. Pharmacother., 2017, 89, 761-771.
[http://dx.doi.org/10.1016/j.biopha.2017.02.056] [PMID: 28273638]
[101]
Nyasse, B.; Nono, J.; Sonke, B.; Denier, C.; Fontaine, C. Trypanocidal activity of bergenin, the major constituent of Flueggea virosa, on Trypanosoma brucei. Pharmazie, 2004, 59(6), 492-494.
[http://dx.doi.org/10.1080/14786410410001709223] [PMID: 15248469]
[102]
Ben, L.; Guo, W.K.; Yuan, H.Y.; Ju, G.M.; Li, G.; Lv, H.Z. Protective effect of aqueous extracts of Securinega suffruticosa (Pall.) Rehd on acute hepatic injury in mice. Sichuan Zhongyi, 2010, 28(02), 25-26.
[103]
Tang, Z.; Wei, S.X.; Liao, H.Z. Effects of aqueous extractive from Flueggea virosa (Roxb. ex Willd.) voigt. on serological markers in rats with hepatic fibrosis. Zhongguo Yiyuan Yongyao Pingjia Yu Fenxi, 2011, 11(07), 621-623.
[104]
Wang, X.M. The study of extraction technology and anti-fatigue activity of securinine. Master Thesis, Jilin Agricultural University: Changchun, 2012.
[105]
Dasgupta, S.; Giri, B.R.; Roy, B. Ultrastructural observations on Raillietina echinobothrida exposed to crude extract and active compound of Securinega virosa. Micron, 2013, 50, 62-67.
[http://dx.doi.org/10.1016/j.micron.2013.05.002] [PMID: 23791913]
[106]
Muthu, C.; Baskar, K.; Kingsley, S.; Ignacimuth, S. Bioefficacy of Clerodendrum phlomidis Linn. f. and Flueggea leucopyrus (Koen.) Willd. against Earias vittella Fab. J. Entomol., 2012, 9(6), 332-342.
[http://dx.doi.org/10.3923/je.2012.332.342]
[107]
Magaji, M.G.; Mohammed, M.; Magaji, R.A.; Musa, A.M.; Abdu, A.I.; Hussaini, I.M. Evaluation of the antipsychotic potential of aqueous fraction of Securinega virosa root bark extract in mice. Metab. Brain Dis., 2014, 29(1), 161-165.
[http://dx.doi.org/10.1007/s11011-014-9483-x] [PMID: 24445435]
[108]
Magaji, M.G.; Musa, A.M.; Abdullahi, M.I.; Ya’u, J.; Hussaini, I.M. Isolation of bergenin from the root bark of Securinega virosa and evaluation of its potential sleep promoting effect. Avicenna J. Phytomed., 2015, 5(6), 587-596.
[PMID: 26693416]
[109]
Magaji, M.G.; Yaro, A.H.; Musa, A.M.; Anuka, J.A.; Abdu, A.I.; Hussaini, I.M. Central depressant activity of butanol fraction of Securinega virosa root bark in mice. J. Ethnopharmacol., 2012, 141(1), 128-133.
[http://dx.doi.org/10.1016/j.jep.2012.02.010] [PMID: 22353430]

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