Title:Application of Probability Based Multi-attribute Optimization in Formulation
of Prescription and Medical Treatment
Volume: 3
Issue: 3
Author(s): Jie Yu and Maosheng Zheng*
Affiliation:
- School of Chemical Engineering., Northwest University,
Xi’an, China
Keywords:
Probability theory, multi-attribute optimization, preferable probability, performance utility indicator, formulation of prescription, medical treatment.
Abstract:
Background: Many drug research problems are multi-objective optimization ones,
such as drug efficacy evaluation, etc. The new concept of preferable probability was introduced in
the probability-based multi-attribute optimization (PMAO) to reflect the preferable degree of the
candidate, which aimed to solve the inherent problems of subjective factors and additive algorithms
in other methods. Furthermore, some medical problems, including optimizations of prescriptions
of drug extraction, are dealt with by using PMAO impersonally.
Objective: The optimizations of prescriptions of drug extraction and the compatibility of the
traditional Chinese medicine design, and the schemes chosen in medical treatment for the cure of
non-small cell lung cancer are conducted by means of PMAO.
Methods: All performance utility indicators of candidates are divided into beneficial or unbeneficial
types, and consistently treated in the scheme selection; each performance utility indicator contributes
a partial preferable probability quantitatively, and the product of all partial preferable
probabilities makes the total preferable probability of a candidate, which thus transfers the multiobject
optimization problem into a single-object optimization one and is the uniquely decisive
index in the selection process.
Results: 1. The drug extraction conditions from schisandra fruit are at 526.79 w microwave power,
75.89% ethanol concentration, 5 min extraction time, 12 times ethanol consumption, and 80
mesh pulverization degree; 2. The optimal compatibility of Lingguishugan Decoction is with
Poria 18 g, Guizhi 13.5 g, Atractylodes 13.5 g, and Licorice 3 g; 3. The pemetrexed is the
appropriate treatment for the commonly used chemotherapy regimens for advanced non-small cell
lung adenocarcinoma comparatively.
Conclusion: This study indicates the applicability of the PMAO in the scheme selection of formulation
of prescription and medical treatment.
