Title:Interpenetrating Polymer Networks of Polyacrylamide with Polyacrylic
and Polymethacrylic Acids and Their Application for Modified Drug
Delivery - a Flash Review
Volume: 11
Issue: 1
Author(s): Marin Simeonov*, Bistra Kostova and Elena Vassileva
Affiliation:
- Laboratory on Structure and Properties of Polymers, Faculty of Chemistry and Pharmacy, University of Sofia, 1, J.
Bourchier blvd., Sofia 1164, Bulgaria
Keywords:
Interpenetrating polymer networks, hydrogel, microgel, drug delivery, poly(acrylic acid), poly(methacrylic acid), polyacrylamide.
Abstract: Polyacrylic and polymethacrylic acids, in combination with polymers such as polyacrylamide,
provide the ability for controlled and sustained drug delivery since they represent pHand
temperature responsiveness. In addition, the synthesis techniques can be used to develop a
higher level of supramolecular structures as the interpenetrating polymer networks - as bulk hydrogels
or micro-/nanogels. They can provide the opportunity to organize and build up state-ofthe-
art carriers for different types of drugs, thus providing the ability to control their loading capacity
and drug release performance. This flash review aims to summarize the efforts for synthesizing
such interpenetrating polymer networks and their properties and to demonstrate the authors'
contributions to this field.