Title:Nanogel Development and its Importance in Ophthalmic Drug Delivery
System
Volume: 12
Issue: 3
Author(s): Sachin S. Gaikwad*, Sahil V. Jadhav and Kishor S. Salunkhe
Affiliation:
- Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, Maharashtra 423603, India
Keywords:
Anatomy of eye, conjunctival, nanogel, ocular drug delivery, polymer, ophthalmic drug delivery system.
Abstract:
Background: The current review focuses on ophthalmic nanogels, their applications,
their benefits over traditional gels, and the challenges and opportunities of nanogels. The major goal
is to investigate ophthalmic nanogels from preparation through characterization and how nanogels
are the future of the ophthalmic drug delivery system compared to traditional gels, eye drops, and
ointments.
Objective: Because of the ophthalmic bioavailability, delivery to the eye is crucial. The lacrimal fluid
in the eye clears the eye surface, and the ocular sight is washed away as a result of this medicine.
The limited ocular bioavailability was also due to the different obstacles present. Drug nano-gelling
systems are effective in improving ocular bioavailability and corneal permeation time. Nanoparticles
abound in these nanogels. Various natural polymers, such as Chitosan and Alginate, and synthetic
polymers, such as PLA and PLGA, can be used to make nanogels. The use of nanotechnology
improves medicine bioavailability and penetration in the eye. However, nanotechnology has some
limits, such as large-scale manufacturing, restricting medicine doses, and so forth.
Conclusion: Nanotechnology offers much clinical potential when it comes to treating eye issues.
Although ophthalmic nanogels are suited for effective drug delivery, they must meet several requirements.
First, the drug component must be encapsulated adequately in a stable polymer complex.
In ocular drug delivery, nanogels are a preferable option since they can improve patient compliance
and therapeutic impact. In addition, the nanogel has a faster corneal penetration time and
higher bioavailability.