Title:Pinpoint and Stewardship of Psoriasis by Using Phytoconstituent-based
Novel Formulation
Volume: 19
Issue: 4
Author(s): Abdul Qadir*, Dipak Kumar Gupta, Shehla Nasar Mir Najib Ullah, Mohd. Aqil, Samreen Jahan and Nausheen Khan
Affiliation:
- Department of Pharmaceutics, School of pharmaceutical education and research, Jamia Hamdard, New Delhi-110062, India
- Department of Research and Developments, Herbalfarm Health care Private Limited, New Delhi, 110020, India
Keywords:
Psoriasis, pathophysiology, novel drug delivery system, phytoconstituent, nanotechnological, technology, inflammatory skin.
Abstract: Psoriasis is an autoimmune skin condition that is also inflammatory and proliferative.
Psoriasis is caused by the activation of T-cells and is distinguished by prominent, drab-red, or
peach-pink tight patches with silvery scales on the skin. In recent years, there have been some significant
advances in the study of the etiology of inflammatory skin diseases such as psoriasis. The
nanotechnology-based novel formulation provides a great occasion for enhancing the efficacy and
safety of pharmacotherapeutic agents for psoriasis. The benefits of nanotechnological techniques to
offer an effective drug concentration in the disease site and nanocarrier as innovative possibilities
for drug delivery systems in psoriasis and other inflammatory chronic skin disorder are highlighted
in this area. We have explored the mechanisms underlying the pathogenic aspects of psoriasis in
this review, as well as phytoconstituents that are naturally occurring substances found in plants
with anti-psoriatic properties. Anti-psoriatic action is attributed to phytochemicals that target cytokine
signaling pathways. We also discussed the benefits of loading phytoconstituents as drugs in
nanocarriers such as liposomes, niosomes, invasomes, phytosomes, transferosomes, and proniosomes
for improved topical therapy and delivery of phytoconstituents with a better therapeutic
profile and lower toxicity.
