Title:Identification of 5F-Cumyl-PINACA, a Synthetic Cannabinoid, in the
Herbal Material Used for Recreational Purposes in the Province of Trieste:
Public Health Implications
Volume: 24
Issue: 6
Author(s): Michela Peruch, Riccardo Addobbati, Martina Padovano, Matteo Scopetti, Monica Concato, Davide Radaelli and Stefano D’Errico*
Affiliation:
- Department of Medicine, Surgery and Health, University of Trieste, Trieste, Italy
Keywords:
5F-Cumyl-PINACA, synthetic cannabinoids, new psychoactive substances, legal high, MRM-IDA-EPI, LC-ESIMS/ MS, Che Sballo platinum, intoxication.
Abstract:
Background: In recent years, the phenomenon of the production and trade of synthetic
cannabinoids has grown, becoming a public health issue worldwide. The recent access- to the ED of
the hospital of Trieste- of people who complained of episodes of hallucinations, sensation of poisoning,
tachycardia, and air hunger following the inhalation of "Che Sballo platinum", have highlighted
the need to perform further analysis on the contents of the packet sold as an air freshener, produced
in Koper (Slovenia).
Objective: This paper wants to be an alert about the possible consequences on health due to the
spreading of “Che Sballo platinum” in the province of Trieste.
Methods: The package contents were analyzed by a multi-target screening method of MRM-IDAEPI
experiment. The result was then confirmed, and quantification was achieved via LC-ESI-MS/MS
analysis in MRM mode using QTrap 6500 + Sinergy hydro column 100 x 2 mm 1.9 um transitions
MRM1 368.3 → 250.0; MRM2 368.3 → 233.0.
Results: The initial screening tested negative for THC and showed positive results for 5F-Cumyl-
PINACA. Quantitation result reported dose by the package of 8.5 mg of the compound. Formal notification
was sent to the Italian Health Authorities (Notification No. 2021110205).
Conclusion: Consumption of 5F-Cumyl-PINACA results in much more potent effects than marijuana.
Lack of information about the actual concentration of the substance on the packaging does not
allow drug users to have an adequate dosage, with possible toxic consequences on health. Further
investigations must be done to discover the true extent of the phenomenon.
