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Review Article

靶向线粒体药物治疗缺血-再灌注损伤

卷 23, 期 16, 2022

发表于: 10 October, 2022

页: [1526 - 1536] 页: 11

弟呕挨: 10.2174/1389450123666220913121422

价格: $65

Open Access Journals Promotions 2
摘要

缺血-再灌注损伤是一种复杂的血流动力学病变，是世界范围内死亡的主要原因，它发生在身体的许多器官中。大量研究表明，线粒体在缺血-再灌注损伤的发生机制中起重要作用，线粒体结构异常和功能障碍导致整个线粒体稳态的破坏。此时，线粒体不仅是产生ATP的亚细胞器，也是调节缺血-再灌注损伤的重要靶点，因此，靶向线粒体的药物可以作为治疗缺血-再灌注损伤的新策略。基于这一观点，本文探讨了线粒体结构异常和线粒体功能障碍的潜在治疗药物，重点探讨了靶向线粒体药物在缺血-再灌注损伤治疗中的应用和前景，并试图为缺血-再灌注损伤的临床治疗提供新的思路

关键词: 缺血-再灌注损伤，靶向线粒体药物，线粒体功能障碍，线粒体膜，药物靶点，活性氧

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