Title:Nanocarriers Based Ocular Therapeutics: Updates, Challenges and Future
Prospectives
Volume: 15
Issue: 1
Author(s): Udesh Kaushal, Malkiet Kaur, Manju Nagpal*, Madhusmita Bhuyan and Kailasam Periyana Gounder
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Punjab, India
Keywords:
Ocular barriers, dendrimers, implants, topical, niosomes, liposomes.
Abstract:
Background: Ocular disorders mainly affect patient’s eyesight and quality of life. Formulation
scientists encounter a hurdle in drug distribution to ocular tissues. Anatomical barriers
(static and dynamic) and physiological barriers, such as nasolacrimal drainage system, blinking
action of eye, and metabolic barriers and efflux pumps, are the principal obstacles to medication
delivery to the posterior and anterior parts. Over the last twenty years, ophthalmic research has
evolved rapidly for the development of innovative, safe, and patient friendly formulations and drug
delivery devices or techniques that may get over these obstacles and sustain drug levels in tissues.
Methods: Literature from the past ten years has been collected using various search engines, such
as ScienceDirect, J-Gate, Google Scholar, Pubmed, Sci-Hub, etc., and research data have been
compiled according to various novel carrier systems.
Results: Nanocarriers have been shown to be helpful in overcoming the drawbacks of traditional
ocular dosing forms. Modification of standard topical solutions by both permeability and viscosity
imparters has resulted in breakthroughs in anterior segment medication delivery. Various nanocarriers,
including liposomes, implants, dendrimers, nanosuspensions, nanoparticles, solid lipid
nanocarriers, niosomes and proniosomes have been studied for enhanced penetration and the successful
targeted drug administration to various ocular locations.
Conclusion: Recently developed nanocarriers for ocular delivery have proved to be cost-effective,
efficacious, safe, and sustained-release carriers, which can be incorporated in suitable dosage
forms.
In this review, the authors have discussed various challenges in ocular drug administration. Various
research reports on advancements in ocular drug delivery based on modified drug delivery
carriers have been analyzed and included. Additionally, marketed formulations and patent literature
on ocular drug delivery have been added as a part to support the review content.
