Title:The Importance of mir-491-5p in Various Cancers
Volume: 23
Issue: 9
关键词:
非编码RNA,microRNA,癌症,Mir-491-5p,转录基因调控,mRNA分解。
摘要: MicroRNAs are non-coding ribonucleic acids that are evolutionarily protected.
MiRNAs control the expression of genes after transcription by mRNA decomposition
or the inhibition of their translation. These molecular structures control physiological
and pathological processes; therefore, many of them can play vital roles as oncogenes
or tumor inhibitors. Besides, the occurrence of various mutations in miRNAs
can lead to cancer. In this review article, we want to peruse the role of miR-491-5p in
various cancers. In recent years, many experiments and studies have been performed
on the involvement of miR-491-5p in cancer, invasion, and cell metastasis. Metastasis
is an event that makes cancer more advanced and harder to treat. When cancer is
invasive, the cancer cells invade nearby tissues or other organs and develop cancer.
Tumor studies have shown that miR-491-5p can inhibit cell growth, invasion, and metastasis.
Thus, expression enhancement of miR-491-5p disrupts cell migration and
improves cancer.