Title:Effective Cancer Management: Inimitable Role of Phytochemical Based Nano-
Formulations
Volume: 23
Issue: 11
Author(s): Aman Upaganlawar*, Satish Polshettiwar, Sushil Raut, Amol Tagalpallewar and Vishal Pande
Affiliation:
- SNJBs SSDJ College of Pharmacy, Neminagar, Chandwad, Maharashtra, India
Keywords:
Cancer, phytochemical, NPs, polymer nanoconjugates, SNEDDS, drug carriers.
Abstract:
Background: Global cancer statistics defines the severity of disease even after significant research
worldwide.
Problem: Failure of the currently available treatment approaches, including surgery, radiation therapy and traditional
chemotherapy.
Aim: The aim of this review is to discuss the role of phytochemical based nano-formulations for treatment of cancer.
Discussion: In the past few decades, phytochemicals have gained popularity for acting as a potential anticancer treatment
with low systemic toxicity, especially in terms of cell cycle control and cancer cell killing. Natural resources, with
their immense structural variety, serve as a vital source of fresh, therapeutically useful new chemical entities for the
treatment of cancer. Vinca alkaloids (VCR), vinblastine, vindesine, vinorelbine, taxanes (PTX), podophyllotoxin and its
derivatives (etoposide (ETP), teniposide, camptothecin (CPT) and its derivatives (topotecan, irinotecan), anthracyclines
(doxorubicin, daunorubicin, epirubicin, idarubicin, as natural products or their derivatives account for half of all anticancer
drugs approved worldwide, and they have been developed utilising the knowledge learned from the natural small
molecules or macromolecules. Trabectedin, an epothilone derivative, ixabepilone, and temsirolimus, three new anticancer
medications launched in 2007, were derived from microbial origins. Current therapy regimens require selective
drug targeting to enhance efficacy against cancer cells while normal cells remain unharmed. Modified medications and
systems for drug delivery based on nanotechnology are in the process of being explored and launched in the industry for
enhanced therapy and management of cancer, along with promising outcomes. Many obstacles related to cancer cell
drug delivery can be overcome by using nano-particulate drug carriers, including enhancing the stability and solubility of
the drug, prolonging half-lives of the drug in the blood, decreasing side effects to undesired organs, and increasing medication
concentration at the desired site. The scientific initiatives and studies concerning the use of nanotechnology for
some selective compounds derived from plants are discussed in this review article.
Conclusion: The present review highlights the phytochemical-based nanoformulations and their strategies in the
development of novel systems of drug delivery such as nano-liposomes, functionalized nanoparticles (NPs), and
polymer nano-conjugates, SNEDDS (Self nano emulsifying drug delivery system) as this review paper depicts, as
well as their rewards over conventional systems of drug delivery, as evidenced by improved biological activity depicted
in their in vitro and in vivo anticancer assays.