Effects of Modafinil (Provigil) on Memory and Learning in Experimental
and Clinical Studies: From Molecular Mechanisms to Behaviour Molecular
Mechanisms and Behavioural Effects

Mohammad   Yassin   Zamanian; Mahdi   Najafiani   Karimvandi; Marjan      Nikbakhtzadeh; Elham      Zahedi; Dmitry   Olegovich   Bokov; Małgorzata      Kujawska; Mahsa      Heidari; Mohammad   Reza   Rahmani

doi:10.2174/1874467215666220901122824

Abstract

Modafinil (MOD, 2‐diphenyl‐methyl‐sulphinil‐2‐acetamide) is a stimulant-like medicine used to treat narcolepsy. Off-label uses include improving cognitive ability in the course of other diseases. This review aims to discuss findings demonstrating the memory and learningenhancing activity of MOD in experimental and clinical studies. We included behavioral evaluations alongside the effects of MOD at the cellular and molecular level.

MOD in different animal disease models exerted beneficial effects on induced memory and learning impairment, which in some cases were accompanied by modulation of neurotransmitter pathways or neuroplastic capabilities, reducing oxidative stress, or expression of synaptic proteins. Individuals treated with MOD showed improved memory and learning skills in different conditions. These effects were associated with regulating brain activity in some participants, confirmed by functional magnetic resonance imaging.

Presented herein, data support the use of MOD in treating memory and learning deficits in various disease conditions.

Keywords: Modafinil, memory, learning, oxidative stress, hippocampus, synaptic plasticity.

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DOI https://dx.doi.org/10.2174/1874467215666220901122824	Print ISSN 1874-4672
Publisher Name Bentham Science Publisher	Online ISSN 1874-4702

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