Title:Novel Formulation Approaches used for the Management of Osteoarthritis:
A Recent Review
Volume: 20
Issue: 7
Author(s): Mohit Kumar, Raghav Dogra and Uttam Kumar Mandal*
Affiliation:
- Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University
(MRSPTU), Bathinda, 151001, Punjab, India
Keywords:
Osteoarthritis, nanoparticle, hydrogel, microsphere, medicinal plants, synthetic drugs.
Abstract:
Background: Osteoarthritis (OA) causes economic, social, and health difficulties in patients.
Approximately 10% to 15% of all persons above the age of 60 have some degree of OA. OA is more
common in women than in males. Diagnosed OA prevalence varies widely among EU member states,
from 2.8% in Romania to 18.3% in Hungary.
Introduction: Osteoarthritis (OA) is a slow-progressing, non-inflammatory disorder. This disorder ultimately
destroys articular cartilage and other joint components. The main symptoms are stiffness, pain,
loss of flexibility, swelling, and bone spurs. Many modifiable and non-modifiable risk factors have been
associated with osteoarthritis (OA), including obesity and lack of exercise, genetic susceptibility, bone
density, work-related damage, and trauma.
Methods: Hydrogels, micro and nano-sized particles, and novel topical gels are the most common examples.
Hydrogels are cross-linked polymers with 3-D architecture that can hold water and expand like
living tissue. The micro-carriers and nano-based drug delivery systems provide several advantages and
may demonstrate prolonged release, controlled release, and higher joint half-life.
Results: OA-induced male Lewis rats were injected with celecoxib-loaded PEA microspheres to assess
in vivo biocompatibility and degradation. According to the findings of this research, PEA microspheres
loaded with celecoxib may be employed as safe delivery of drugs with self-regulating behavior for pain
treatment related to knee osteoarthritis.
Conclusion: The concept of novel drug delivery systems has shown tangible benefits as a new avenue
for precise, safe, high-quality drug delivery for OA treatment. Currently, herbal drugs are also used in
osteoarthritis treatment due to their potency and fewer side effects than synthetic drugs. The herbosynthetic
approach is a new concept for the delivery of both herbal and synthetic drugs together to exploit
their individual beneficial effects while reducing undesirable side effects.
