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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Review Article

The Roles and Regulation of Ferroptosis in Cancer Progression

Author(s): Yu yang, Te Ma, Ting Hu, Chengcheng Ma, Huiqing Tu and Shunqin Zhu*

Volume 26, Issue 6, 2023

Published on: 08 November, 2022

Page: [1141 - 1148] Pages: 8

DOI: 10.2174/1386207325666220831151036

Price: $65

Abstract

Ferroptosis is an iron-dependent, nonapoptotic form of regulatory death and has received extensive attention. Fenton reaction related to iron metabolism release high levels of Reactive Oxygen Species (ROS), and the intracellular ROS content is closely related to various diseases; the iron ion concentration in many diseased cells is also disordered. In this paper, the advances in ferroptosis research are summarized, and the regulatory mechanisms of ferroptosis, including inducers and regulatory protein of ferroptosis in cancer progression. We expect that this study will benefit the further development of basic research and clinical application of ferroptosis for cancer treatment.

Keywords: Ferroptosis, ROS, cancer progression, system Xc-, GPX4, cell death.

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