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Review Article

The Role of Leukocyte Immunoglobulin-Like Receptors Focusing on the Therapeutic Implications of the Subfamily B2

Author(s): Yanyu Hu, Xin Lu, Weimin Qiu, Hui Liu, Qinghua Wang, Yao Chen, Wenyuan Liu, Feng Feng* and Haopeng Sun*

Volume 23, Issue 15, 2022

Published on: 21 September, 2022

Page: [1430 - 1452] Pages: 23

DOI: 10.2174/1389450123666220822201605

Price: $65

Abstract

The leukocyte immunoglobulin (Ig)-like receptors (LILRs) are constituted by five inhibitory subpopulations (LILRB1-5) and six stimulatory subpopulations (LILRA1-6). The LILR populations substantially reside in immune cells, especially myeloid cells, functioning as a regulator in immunosuppressive and immunostimulatory responses, during which the nonclassical major histocompatibility complex (MHC) class I molecules are widely involved. In addition, LILRs are also distributed in certain tumor cells, implicated in the malignancy progression. Collectively, the suppressive Ig-like LILRB2 is relatively well-studied to date. Herein, we summarized the whole family of LILRs and their biologic function in various diseases upon ligation to the critical ligands, therefore providing more information on their potential roles in these pathological processes and giving the clinical significance of strategies targeting LILRs.

Keywords: Leukocyte immunoglobulin-like receptors, leukocyte immunoglobulin-like receptor B2, LILRs-related diseases, MHC-I, immunotherapy, cancer.

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