Protective or Inhibitory Effect of Pharmacological Therapy on Cardiac Ischemic
Preconditioning: A Literature Review

Leonardo   Jorge Cordeiro   de Paula; Augusto   Hiroshi   Uchida; Paulo   Cury   Rezende; Paulo      Soares; Thiago   Luis   Scudeler
doi:10.2174/1570161120666220819163025
Abstract

Ischemic preconditioning (IP) is an innate phenomenon, triggered by brief, non-lethal cycles of ischemia/reperfusion applied to a tissue or organ that confers tolerance to a subsequent more prolonged ischemic event. Once started, it can reduce the severity of myocardial ischemia associated with some clinical situations, such as percutaneous coronary intervention (PCI) and intermittent aortic clamping during coronary artery bypass graft surgery (CABG). Although the mechanisms underlying IP have not been completely elucidated, several studies have shown that this phenomenon involves the participation of cell triggers, intracellular signaling pathways, and end-effectors. Understanding this mechanism enables the development of preconditioning mimetic agents. It is known that a range of medications that activate the signaling cascades at different cellular levels can interfere with both the stimulation and the blockade of IP. Investigations of signaling pathways underlying ischemic conditioning have identified a number of therapeutic targets for pharmacological manipulation. This review aims to present and discuss the effects of several medications on myocardial IP.
Keywords: Ischemic preconditioning, cardiac pharmacology, ischemia-reperfusion injury, heart disease, signaling pathways, cardioprotection.
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/1570161120666220819163025	Print ISSN 1570-1611
Publisher Name Bentham Science Publisher	Online ISSN 1875-6212
Current Vascular Pharmacology

Protective or Inhibitory Effect of Pharmacological Therapy on Cardiac Ischemic Preconditioning: A Literature Review

Abstract

Graphical Abstract

Advancements in Arterial Stiffness: Novel Therapeutic Frontiers

TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE

Current Vascular Pharmacology

Protective or Inhibitory Effect of Pharmacological Therapy on Cardiac Ischemic Preconditioning: A Literature Review

Abstract

Graphical Abstract

Call for Papers in Thematic Issues

Advancements in Arterial Stiffness: Novel Therapeutic Frontiers

TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE

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