Title:The Effect of Bacterial Composition Shifts in the Oral Microbiota
on Alzheimer's Disease
Volume: 24
Issue: 2
关键词:
口腔微生物组、阿尔茨海默病、肠道微生物组、微生态失调、牙周炎、微生物。
摘要: Alzheimer's disease (AD), a neurological disorder, despite significant
advances in medical science, has not yet been definitively cured, and the exact causes
of the disease remain unclear. Due to the importance of AD in the clinic, large expenses
are spent annually to deal with this neurological disorder, and neurologists warn of an
increase in this disease in elderly in the near future. It has been believed that microbiota
dysbiosis leads to Alzheimer’s as a multi-step disease. In this regard, the presence of
footprints of perturbations in the oral microbiome and the predominance of pathogenic
bacteria and their effect on the nervous system, especially AD, is a very interesting topic
that has been considered by researchers in the last decade. Some studies have looked
at the mechanisms by which oral microbiota cause AD. However, many aspects of this
interaction are still unclear as to how oral microbiota composition can contribute to this
disease. Understanding this interaction requires extensive collaboration by
interdisciplinary researchers to explore all aspects of the issue. In order to reveal the
link between the composition of the oral microbiota and this disease, researchers from
various domains have sought to explain the mechanisms of shift in oral microbiota in AD
in this review.
