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Review Article

相扑和SUMO化在糖尿病发病机制中的潜在作用

卷 30, 期 14, 2023

发表于: 23 September, 2022

页: [1623 - 1637] 页: 15

弟呕挨: 10.2174/0929867329666220817142848

价格: $65

摘要

糖尿病是一组以高血糖为特征的代谢紊乱，与多器官系统并发症有关。糖尿病的发病率和患病率在世界范围内以流行病的比例增加。除环境因素外，一些表观遗传学和翻译后修饰在糖尿病及其并发症的发病机制中起关键作用。可逆共价修饰，例如SUMO化SUMO化（小泛素样修饰剂）已成为影响蛋白质动态调节的新机制。在这篇综述中，我们首先关注相扑和相扑的功能。随后，我们评估了该过程在1型和2型糖尿病发病机制中的潜在影响。

关键词: 糖尿病，小泛素样修饰剂，相扑，SUMO化，高血糖，表观遗传

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