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Review Article

肿瘤氧化还原平衡中的半胱氨酸代谢

卷 30, 期 16, 2023

发表于: 22 September, 2022

页: [1813 - 1823] 页: 11

弟呕挨: 10.2174/0929867329666220817141227

价格: $65

摘要

半胱氨酸（Cys）是一种半必需的营养氨基酸，通过内源性生产和各种运输系统在细胞中发挥重要作用。细胞内Cys可作为蛋白质合成的前体，以维持细胞内稳态并生成含硫物质，包括谷胱甘肽（GSH）、硫化氢（H2S）和牛磺酸。已有相当多的报道表明Cys与肿瘤的发生和发展有关，其水平与肿瘤的增殖、侵袭和转移密切相关。此外，它有助于维持肿瘤氧化还原平衡和增加耐药性。本文综述了胱氨酸的产生、代谢及其在肿瘤中的作用，特别强调了胱胺酸在肿瘤中对提高癌症患者生活质量的潜在治疗价值。

关键词: 半胱氨酸、代谢、肿瘤、氧化还原稳态、肿瘤治疗、谷胱甘肽。

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