Generic placeholder image

Current Rheumatology Reviews

Editor-in-Chief

ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Review Article

Lymphocytic Interstitial Pneumonia Associated with Sjögren Syndrome: Case-Based Review

Author(s): Caio Marco Gonçalves, Luísa Rodrigues Cordeiro, Carlos Augusto Ferreira de Andrade and Jozélio Freire de Carvalho*

Volume 19, Issue 1, 2023

Published on: 02 September, 2022

Page: [1 - 6] Pages: 6

DOI: 10.2174/1573397118666220817091520

Price: $65

Abstract

Background: Few studies have described lymphocytic interstitial pneumonia (LIP) in Sjögren's syndrome (SS). We aimed to analyze the clinical, therapeutic, and outcome of patients with SS and LIP.

Methods: We searched for articles in PubMed/MEDLINE, LILACS, SciELO, and Cochrane from 1966 to 2020, in English, Spanish, French, Chinese, and Japanese literature had an English summary about LIP and SS. The keywords were "Sjögren syndrome" and "Lymphocytic interstitial pneumonia." Additionally, we report a patient with SS and LIP.

Results: 27 patients with SS and LIP were found. The age range ranged from 14 to 73 years old, with only 3 male patients, with a predominance of LIP cases in patients with primary SS (22/27). In the following case, the LIP preceded SS by 2 years; in the other 26 patients, SS preceded it. The majority presented dyspnea, mainly on exertion, followed by a dry cough. Lung biopsy was performed in 10 studies. Therapy varied from the use of clinical observation, corticosteroids alone, or associated with immunosuppressants. Most studies have shown improvement or stabilization of the pulmonary condition after therapy (13/16 studies).

Conclusion: This article reviews cases of lymphocytic interstitial pneumonia associated with Sjögren syndrome and shows a good outcome with adequate treatment. It emphasizes that early LIP diagnosis in patients with Sjogren Syndrome may be determined using lung computed tomography.

Keywords: Sjögren syndrome, pneumonitis, lymphocytic interstitial pneumonia, lungs, bronchiolitis obliterans, pulmonary fibrosis.

Next »
Graphical Abstract
[1]
Thorne I, Sutcliffe N. Sjögren’s syndrome. Br, Hosp J 2017; 78(8): 438-2.
[http://dx.doi.org/10.12968/hmed.2017.78.8.438]
[2]
Patel R, Shahane A. The epidemiology of Sjögren’s syndrome. Clin Epidemiol 2014; 6: 247-55.
[http://dx.doi.org/10.2147/CLEP.S47399] [PMID: 25114590]
[3]
Ramos-Casals M, Brito-Zerón P, Sisó-Almirall A, Bosch X. Primary sjogren syndrome. BMJ 2012; 344: e3821.
[http://dx.doi.org/10.1136/bmj.e3821] [PMID: 22700787]
[4]
Mavragani CP, Moutsopoulos HM. Sjögren syndrome. CMAJ 2014; 186(15): E579-86.
[http://dx.doi.org/10.1503/cmaj.122037] [PMID: 24566651]
[5]
Ferreira D, Neves S, Lira A, Bastos I, Almeida J. Pulmonary manifestations of autoimmune diseases. Rev Port Pneumol 2007; 13(1): 83-100.
[http://dx.doi.org/10.1016/S0873-2159(15)30339-1] [PMID: 17315092]
[6]
Stojan G, Baer AN, Danoff SK. Pulmonary manifestations of Sjögren’s syndrome. Curr Allergy Asthma Rep 2013; 13(4): 354-60.
[http://dx.doi.org/10.1007/s11882-013-0357-9] [PMID: 23797265]
[7]
Andoh M, Seike M, Kurimoto F, et al. Lymphocytic interstitial pneumonia associated with Sjögren’s syndrome and mediastinal lymphadenopathy: Diagnosis by open-lung biopsy. Nihon Kyobu Shikkan Gakkai Zasshi 1997; 35(3): 346-51.
[PMID: 9168654]
[8]
Houghton KM, Cabral DA, Petty RE, Tucker LB. Primary Sjögren’s syndrome in dizygotic adolescent twins: One case with lymphocytic interstitial pneumonia. J Rheumatol 2005; 32(8): 1603-6.
[PMID: 16078341]
[9]
Kim J-Y, Park S-H, Kim S-K, et al. Lymphocytic interstitial pneumonia in primary Sjögren’s syndrome: A case report. Korean J Intern Med (Korean Assoc Intern Med) 2011; 26(1): 108-11.
[http://dx.doi.org/10.3904/kjim.2011.26.1.108] [PMID: 21437172]
[10]
Schuurman HJ, Gooszen HC, Tan IW, Kluin PM, Wagenaar SS, van Unnik JA. Low-grade lymphoma of immature T-cell phenotype in a case of lymphocytic interstitial pneumonia and Sjögren’s syndrome. Histopathology 1987; 11(11): 1193-204.
[http://dx.doi.org/10.1111/j.1365-2559.1987.tb01859.x] [PMID: 3500906]
[11]
Parambil JG, Myers JL, Lindell RM, Matteson EL, Ryu JH. Interstitial lung disease in primary sjögren syndrome. Chest 2006; 130(5): 1489-95.
[http://dx.doi.org/10.1378/chest.130.5.1489] [PMID: 17099028]
[12]
Yan S-M, Zhao Y, Zeng X-F, Zhang F-C, Dong Y. Lung involvement of primary Sjögren’s syndrome. Zhonghua Jie He He Hu Xi Za Zhi 2008; 31(7): 513-6.
[PMID: 19035231]
[13]
Dong X, Zhou J, Guo X, et al. A retrospective analysis of distinguishing features of chest HRCT and clinical manifestation in primary Sjögren’s syndrome-related interstitial lung disease in a Chinese population. Clin Rheumatol 2018; 37(11): 2981-8.
[http://dx.doi.org/10.1007/s10067-018-4289-6] [PMID: 30242640]
[14]
Garcia D, Young L. Lymphocytic interstitial pneumonia as a manifestation of SLE and secondary Sjogren’s syndrome. BMJ Case Rep 2013; 2013: bcr2013009598.
[http://dx.doi.org/10.1136/bcr-2013-009598] [PMID: 23912652]
[15]
Totani Y, Demura Y, Ameshima S, Miyamori I, Ishizaki T. A case of lymphocytic interstitial pneumonia with Sjögren’s syndrome and systemic lupus erythematosus in which human herpes virus-6 infection was the suspected pathogen. Nihon Kokyuki Gakkai Zasshi 2001; 39(10): 763-9.
[PMID: 11828732]
[16]
Allard P, Kermarec J, L’Her P, Natali F, Lebarbu M, Le Vagueresse R. Lymphocytic interstitial pneumonia in Gougerot-Sjögren syndrome with scleroderma. Ann Med Interne 1984; 135(6): 431-4.
[PMID: 6508046]
[17]
Ahmed F, Raslan O, Muzaffar R, Parkar N, Marwaha N, Osman MM. Sjögren syndrome complicated by mucosa-associated lymphoid tissue lymphoma and lymphocytic interstitial pneumonia. Front Oncol 2015; 5: 179.
[http://dx.doi.org/10.3389/fonc.2015.00179] [PMID: 26301203]
[18]
Bryson T, Sundaram B, Khanna D, Kazerooni EA. Connective tissue disease-associated interstitial pneumonia and idiopathic interstitial pneumonia: Similarity and difference. Semin Ultrasound, CT MRI 2014; 35(1): 29-38.
[http://dx.doi.org/10.1053/j.sult.2013.10.010] [PMID: 24480141]
[19]
Panchabhai TS, Farver C, Highland KB. Lymphocytic interstitial pneumonia. Clin Chest Med 2016; 37(3): 463-74.
[http://dx.doi.org/10.1016/j.ccm.2016.04.009] [PMID: 27514593]
[20]
Obaidat B, Yazdani D, Wikenheiser-Brokamp KA, Gupta N. Diffuse cystic lung diseases. Respir Care 2020; 65(1): 111-26.
[http://dx.doi.org/10.4187/respcare.07117] [PMID: 31615921]
[21]
Elzbieta R, Elzbieta W, Dariusz G, Langfort R, Ptak J. Lymphocytic interstitial pneumonia in primary Sjögren syndrome. Pneumonol Alergol Pol 2005; 73(3): 277-80.
[PMID: 16989166]
[22]
Tsukiji J, Kaneko T, Inoue M, et al. A case of lymphocytic interstitial pneumonia complicated with primary Sjögren’s syndrome followed by chest CT scanning for thirteen years. Nihon Kokyuki Gakkai Zasshi 2009; 47(2): 151-7.
[PMID: 19260540]
[23]
Thompson G, Mclean-Tooke A, Wrobel J, Lavender M, Lucas M. Sjögren syndrome with associated lymphocytic interstitial pneumonia successfully treated with tacrolimus and abatacept as an alternative to rituximab. Chest 2018; 153(3): e41-3.
[http://dx.doi.org/10.1016/j.chest.2017.12.010] [PMID: 29519308]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy