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Review Article

伊维菌素在缓解新冠病毒诱导的自治障碍中的中心作用

卷 23, 期 13, 2022

发表于: 05 September, 2022

页: [1277 - 1287] 页: 11

弟呕挨: 10.2174/1389450123666220810102406

价格: $65

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摘要

Covid-19可能与各种神经障碍有关，包括自主神经系统(ANS)功能障碍——自主神经障碍。在Covid-19中，缺氧、免疫炎症异常和肾素-血管紧张素系统(RAS)的失调可能会增加交感神经放电，并伴有自治障碍的发展。直接的SARS-CoV-2细胞病变效应和相关炎症反应可能导致神经炎症，影响中枢神经系统(CNS)的不同部位，包括下丘脑的自主中枢，导致自主功能障碍。高循环AngII、缺氧、氧化应激、高促炎细胞因子和情绪应激也可随着交感神经风暴的发展引起自主神经失调和高交感神经流出。在伴有神经侵袭的SARS-CoV-2感染过程中，下丘脑交感前神经元中的GABA能神经元和尼古丁乙酰胆碱受体(nAChR)受到抑制，导致交感神经风暴和自主障碍。不同的治疗方法被用于治疗SARS-CoV-2感染，如抗病毒和抗炎药物。伊维菌素(IVM)是一种强大的改用药物，广泛用于预防和治疗轻-中度Covid-19。IVM激活GABA能神经元和nAChRs，以缓解SARS-CoV-2感染诱导的自治障碍。因此，在这篇简短的报告中，我们试图确定IVM在管理covid -19诱导的自治障碍方面的潜在作用。

关键词: 新冠病毒，GABA能神经元，伊维菌素，自主神经障碍，尼古丁乙酰胆碱受体，神经炎症。

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