Title:Dexamethasone Loaded Electrospun Nanocomposite Ocular Insert:
In-vitro Drug Release and Mechanical Assessment
Volume: 12
Issue: 2
Author(s): Rishabh Agarwal, Dhwani Rana, Sagar Salave and Derajram Benival*
Affiliation:
- Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, India.
Keywords:
Dexamethasone, ocular insert, electrospinning, nanocomposite, ocular drug delivery, conjunctival sac.
Abstract:
Background: Dexamethasone is currently available as a suspension for the treatment of
anterior ocular inflammatory diseases that are given through eye drops. However, less than 5% of
the drug gets absorbed when applied topically as eye drops. The major portion of administered drug
either comes out from the eye or gets subjected to nasolacrimal drainage, resulting in poor bioavailability.
Objective: The present study aims to develop a polymeric ocular insert containing dexamethasone
as a drug by employing the electrospinning technique.
Methods: Dexamethasone (0.1% w/v) loaded electrospun sheet was also made using 10% w/v EC:
HPMC: PEO (60:20:20) in a solvent system of ethanol: water (90:10) at optimized electrospinning
parameters of 12kV with a flow rate of 0.8mL/hr and distance of 20 cm between tip and collector.
Results: The prepared nanocomposite insert was characterized for DSC and FTIR-ATR spectroscopy,
revealing no physical-chemical interaction between drugs with polymers. The thickness of the
electrospun sheet was found to be 270±0.02 μm, and % the drug content was found to be
0.43±0.01% w/w. The release profile showed that around 95% drug was released in 48 hrs. This release
profile showed that the prepared drug-loaded electrospun ocular insert is best suitable for
once-a-day delivery. Assessment of mechanical properties like young’s modulus, tensile strength,
and % elongation showed that the prepared insert could be handled easily without any breakage or
damage.
Conclusion: Upon delivery in the conjunctival sac, the developed insert is best suitable for once-aday
delivery. The developed electrospun insert, consisting of a unique polymer composite of biodegradable
polymers, avails the benefits of nanofibers imparting prolonged release, and this novel
formulation overcomes the limitations of conventional therapies. This reduces the dosing frequency
and improves patient compliance.