Title:Assessing the Influence of Salvia triloba on Memory Deficit Caused by
Sleep Deprivation in the Context of Oxidative Stress
Volume: 19
Issue: 6
关键词:
鼠尾草、过氧化氢酶、迷宫、脑源性神经营养因子、谷胱甘肽、睡眠剥夺。
摘要:
Background: Learning and memory deficit has been reported to be correlated to oxidative
mutilation in the hippocampus. Moreover, sleep deprivation (SD) mitigates memory via distressing
oxidative stress balance. In the current report, the prospective neuroprotective role of oral sage (Salvia
triloba) extract on cognitive impairment induced by chronic SD was investigated.
Methods: The SD was induced in adult male Wistar rats employing a modified multiple platform (8
h/day; for six weeks). Simultaneously, S. triloba extract (375 mg/kg, orally) was administered for six
weeks. Thereafter, the Radial Arm Water Maze test was utilized to evaluate spatial learning and
memory. Moreover, activities of different hippocampal antioxidant parameters: glutathione peroxidase
(GPx), oxidized glutathione (GSSG), reduced glutathione (GSH), catalase, superoxide dismutase
(SOD), and the thiobarbituric acid reactive substance (TBARS) were measured in rats’ hippocampus.
Moreover, the level of brain derived neurotrophic factor (BDNF) was assessed.
Results: Current results illustrate that chronic SD significantly compromised both memories, shortand
long-term, while sage extract inhibited these consequences. Moreover, sage extract remarkably
stabilized the antioxidant enzyme levels, which were decreased by SD, such as: SOD, catalase, and
GPx (P < 0.05), and remarkably augmented the GSH/GSSG ratio in SD rats (P < 0.05). However, no
substantial alterations of GSH, TBARS or BDNF levels (P > 0.05) were seen with sage extract administration.
Conclusion: Chronic treatment with sage extract (S. Triloba) precluded SD-induced memory impairment
by regularizing antioxidant parameters levels in rats’ hippocampus.
