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Current Drug Metabolism

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ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

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Review Article

Nanoparticle-Based Inhalation Therapy for Pulmonary Diseases

Author(s): Dhananjay Yadav, Peninah M. Wairagu, Minseok Kwak* and Jun-O Jin*

Volume 23, Issue 11, 2022

Published on: 08 November, 2022

Page: [882 - 896] Pages: 15

DOI: 10.2174/1389200223666220803103039

Price: $65

Abstract

The lung is exposed to various pollutants and is the primary site for the onset of various diseases, including infections, allergies, and cancers. One possible treatment approach for such pulmonary diseases involves direct administration of therapeutics to the lung so as to maintain the topical concentration of the drug. Particles with nanoscale diameters tend to reach the pulmonary region. Nanoparticles (NPs) have garnered significant interest for applications in biomedical and pharmaceutical industries because of their unique physicochemical properties and biological activities. In this article, we describe the biological and pharmacological activities of NPs as well as summarize their potential in the formulation of drugs employed to treat pulmonary diseases. Recent advances in the use of NPs in inhalation chemotherapy for the treatment of lung diseases have also been highlighted.

Keywords: Natural polymer, nanoparticle, respiratory disease, biomedical applications, lung therapy, phagocytosis.

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