Effects of Acylhydrazone Derivatives on Experimental Pulmonary Inflammation by Chemical Sensitization

Huang, C.; Wang, Y.; Li, X.; Ren, L.; Zhao, J.; Hu, Y.; Zhang, L.; Fan, G.; Xu, J.; Gu, X.; Cheng, Z.; Yu, T.; Xia, J.; Wei, Y.; Wu, W.; Xie, X.; Yin, W.; Li, H.; Liu, M.; Xiao, Y.; Gao, H.; Guo, L.; Xie, J.; Wang, G.; Jiang, R.; Gao, Z.; Jin, Q.; Wang, J.; Cao, B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 2020, 395(10223), 497-506.
[http://dx.doi.org/10.1016/S0140-6736(20)30183-5] [PMID: 31986264]

Wu, C.Y.; Lin, Y.S.; Yang, Y.H.; Shu, L.H.; Cheng, Y.C.; Liu, H.T. GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies. Biomed. Pharmacother., 2020, 132, 110816.
[http://dx.doi.org/10.1016/j.biopha.2020.110816] [PMID: 33049583]

Zhou, P.; Yang, X.L.; Wang, X.G.; Hu, B.; Zhang, L.; Zhang, W.; Si, H.R.; Zhu, Y.; Li, B.; Huang, C.L.; Chen, H.D.; Chen, J.; Luo, Y.; Guo, H.; Jiang, R.D.; Liu, M.Q.; Chen, Y.; Shen, X.R.; Wang, X.; Zheng, X.S.; Zhao, K.; Chen, Q.J.; Deng, F.; Liu, L.L.; Yan, B.; Zhan, F.X.; Wang, Y.Y.; Xiao, G.F.; Shi, Z.L. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 2020, 579(7798), 270-273.
[http://dx.doi.org/10.1038/s41586-020-2012-7] [PMID: 32015507]

The Lancet. GBD 2020 Chronic Respiratory Disease Collaborators. Global health: Time for radical change? Lancet, 2020, 396(10258), 396-e1125.
[http://dx.doi.org/10.1016/S0140-6736(20)32131-0]

Alhassan, S.; Hattab, Y.; Bajwa, O.; Bihler, E.; Singh, A.C. Asthma. Crit. Care Nurs. Q., 2016, 39(2), 110-123.
[http://dx.doi.org/10.1097/CNQ.0000000000000104] [PMID: 26919672]

Taniguchi, H.; Kondoh, Y. Acute and subacute idiopathic interstitial pneumonias. Respirology, 2016, 21(5), 810-820.
[http://dx.doi.org/10.1111/resp.12786] [PMID: 27123874]

Kolb, M.; Bondue, B.; Pesci, A.; Miyazaki, Y.; Song, J.W.; Bhatt, N.Y.; Huggins, J.T.; Oldham, J.M.; Padilla, M.L.; Roman, J.; Shapera, S. Acute exacerbations of progressive-fibrosing interstitial lung diseases. Eur. Respir. Rev., 2018, 27(150), e180071.
[http://dx.doi.org/10.1183/16000617.0071-2018] [PMID: 30578331]

Wang, H.; Naghavi, M.; Allen, C.; Barber, R.M.; Bhutta, Z.A.; Carter, A.; Casey, D.C.; Charlson, F.J.; Chen, A.Z.; Coates, M.M.; Coggeshall, M.; Dandona, L.; Dicker, D.J.; Erskine, H.E.; Ferrari, A.J.; Fitzmaurice, C.; Foreman, K.; Forouzanfar, M.H.; Fraser, M.S.; Fullman, N.; Gething, P.W.; Goldberg, E.M.; Graetz, N.; Haagsma, J.A.; Hay, S.I.; Huynh, C.; Johnson, C.O.; Kassebaum, N.J.; Kinfu, Y.; Kulikoff, X.R.; Kutz, M.; Kyu, H.H.; Larson, H.J.; Leung, J.; Liang, X.; Lim, S.S.; Lind, M.; Lozano, R.; Marquez, N.; Mensah, G.A.; Mikesell, J.; Mokdad, A.H.; Mooney, M.D.; Nguyen, G.; Nsoesie, E.; Pigott, D.M.; Pinho, C.; Roth, G.A.; Salomon, J.A.; Sandar, L.; Silpakit, N.; Sligar, A.; Sorensen, R.J.D.; Stanaway, J.; Steiner, C.; Teeple, S.; Thomas, B.A.; Troeger, C.; VanderZanden, A.; Vollset, S.E.; Wanga, V.; Whiteford, H.A.; Wolock, T.; Zoeckler, L.; Abate, K.H.; Abbafati, C.; Abbas, K.M.; Abd-Allah, F.; Abera, S.F.; Abreu, D.M.X.; Abu-Raddad, L.J.; Abyu, G.Y.; Achoki, T.; Adelekan, A.L.; Ademi, Z.; Adou, A.K.; Adsuar, J.C.; Afanvi, K.A.; Afshin, A.; Agardh, E.E.; Agarwal, A.; Agrawal, A.; Kiadaliri, A.A.; Ajala, O.N.; Akanda, A.S.; Akinyemi, R.O.; Akinyemiju, T.F.; Akseer, N.; Lami, F.H.A.; Alabed, S.; Al-Aly, Z.; Alam, K.; Alam, N.K.M.; Alasfoor, D.; Aldhahri, S.F.; Aldridge, R.W.; Alegretti, M.A.; Aleman, A.V.; Alemu, Z.A.; Alexander, L.T.; Alhabib, S.; Ali, R.; Alkerwi, A.; Alla, F.; Allebeck, P.; Al-Raddadi, R.; Alsharif, U.; Altirkawi, K.A.; Martin, E.A.; Alvis-Guzman, N.; Amare, A.T.; Amegah, A.K.; Ameh, E.A.; Amini, H.; Ammar, W.; Amrock, S.M.; Andersen, H.H.; Anderson, B.O.; Anderson, G.M.; Antonio, C.A.T.; Aregay, A.F.; Ärnlöv, J.; Arsenijevic, V.S.A.; Artaman, A.; Asayesh, H.; Asghar, R.J.; Atique, S.; Avokpaho, E.F.G.A.; Awasthi, A.; Azzopardi, P.; Bacha, U.; Badawi, A.; Bahit, M.C.; Balakrishnan, K.; Banerjee, A.; Barac, A.; Barker-Collo, S.L.; Bärnighausen, T.; Barregard, L.; Barrero, L.H.; Basu, A.; Basu, S.; Bayou, Y.T.; Bazargan-Hejazi, S.; Beardsley, J.; Bedi, N.; Beghi, E.; Belay, H.A.; Bell, B.; Bell, M.L.; Bello, A.K.; Bennett, D.A.; Bensenor, I.M.; Berhane, A.; Bernabé, E.; Betsu, B.D.; Beyene, A.S.; Bhala, N.; Bhalla, A.; Biadgilign, S.; Bikbov, B.; Abdulhak, A.A.B.; Biroscak, B.J.; Biryukov, S.; Bjertness, E.; Blore, J.D.; Blosser, C.D.; Bohensky, M.A.; Borschmann, R.; Bose, D.; Bourne, R.R.A.; Brainin, M.; Brayne, C.E.G.; Brazinova, A.; Breitborde, N.J.K.; Brenner, H.; Brewer, J.D.; Brown, A.; Brown, J.; Brugha, T.S.; Buckle, G.C.; Butt, Z.A.; Calabria, B.; Campos-Nonato, I.R.; Campuzano, J.C.; Carapetis, J.R.; Cárdenas, R.; Carpenter, D.O.; Carrero, J.J.; Castañeda-Orjuela, C.A.; Rivas, J.C.; Catalá-López, F.; Cavalleri, F.; Cercy, K.; Cerda, J.; Chen, W.; Chew, A.; Chiang, P.P-C.; Chibalabala, M.; Chibueze, C.E.; Chimed-Ochir, O.; Chisumpa, V.H.; Choi, J-Y.J.; Chowdhury, R.; Christensen, H.; Christopher, D.J.; Ciobanu, L.G.; Cirillo, M.; Cohen, A.J.; Colistro, V.; Colomar, M.; Colquhoun, S.M.; Cooper, C.; Cooper, L.T.; Cortinovis, M.; Cowie, B.C.; Crump, J.A.; Damsere-Derry, J.; Danawi, H.; Dandona, R.; Daoud, F.; Darby, S.C.; Dargan, P.I. das Neves, J.; Davey, G.; Davis, A.C.; Davitoiu, D.V.; de Castro, E.F.; de Jager, P.; Leo, D.D.; Degenhardt, L.; Dellavalle, R.P.; Deribe, K.; Deribew, A.; Dharmaratne, S.D.; Dhillon, P.K.; Diaz-Torné, C.; Ding, E.L.; dos Santos, K.P.B.; Dossou, E.; Driscoll, T.R.; Duan, L.; Dubey, M.; Duncan, B.B.; Ellenbogen, R.G.; Ellingsen, C.L.; Elyazar, I.; Endries, A.Y.; Ermakov, S.P.; Eshrati, B.; Esteghamati, A.; Estep, K.; Faghmous, I.D.A.; Fahimi, S.; Faraon, E.J.A.; Farid, T.A.; Farinha, C.S.S.; Faro, A.; Farvid, M.S.; Farzadfar, F.; Feigin, V.L.; Fereshtehnejad, S-M.; Fernandes, J.G.; Fernandes, J.C.; Fischer, F.; Fitchett, J.R.A.; Flaxman, A.; Foigt, N.; Fowkes, F.G.R.; Franca, E.B.; Franklin, R.C.; Friedman, J.; Frostad, J.; Fürst, T.; Futran, N.D.; Gall, S.L.; Gambashidze, K.; Gamkrelidze, A.; Ganguly, P.; Gankpé, F.G.; Gebre, T.; Gebrehiwot, T.T.; Gebremedhin, A.T.; Gebru, A.A.; Geleijnse, J.M.; Gessner, B.D.; Ghoshal, A.G.; Gibney, K.B.; Gillum, R.F.; Gilmour, S.; Giref, A.Z.; Giroud, M.; Gishu, M.D.; Giussani, G.; Glaser, E.; Godwin, W.W.; Gomez-Dantes, H.; Gona, P.; Goodridge, A.; Gopalani, S.V.; Gosselin, R.A.; Gotay, C.C.; Goto, A.; Gouda, H.N.; Greaves, F.; Gugnani, H.C.; Gupta, R.; Gupta, R.; Gupta, V.; Gutiérrez, R.A.; Hafezi-Nejad, N.; Haile, D.; Hailu, A.D.; Hailu, G.B.; Halasa, Y.A.; Hamadeh, R.R.; Hamidi, S.; Hancock, J.; Handal, A.J.; Hankey, G.J.; Hao, Y.; Harb, H.L.; Harikrishnan, S.; Haro, J.M.; Havmoeller, R.; Heckbert, S.R.; Heredia-Pi, I.B.; Heydarpour, P.; Hilderink, H.B.M.; Hoek, H.W.; Hogg, R.S.; Horino, M.; Horita, N.; Hosgood, H.D.; Hotez, P.J.; Hoy, D.G.; Hsairi, M.; Htet, A.S.; Htike, M.M.T.; Hu, G.; Huang, C.; Huang, H.; Huiart, L.; Husseini, A.; Huybrechts, I.; Huynh, G.; Iburg, K.M.; Innos, K.; Inoue, M.; Iyer, V.J.; Jacobs, T.A.; Jacobsen, K.H.; Jahanmehr, N.; Jakovljevic, M.B.; James, P.; Javanbakht, M.; Jayaraman, S.P.; Jayatilleke, A.U.; Jeemon, P.; Jensen, P.N.; Jha, V.; Jiang, G.; Jiang, Y.; Jibat, T.; Jimenez-Corona, A.; Jonas, J.B.; Joshi, T.K.; Kabir, Z.; Kamal, R.; Kan, H.; Kant, S.; Karch, A.; Karema, C.K.; Karimkhani, C.; Karletsos, D.; Karthikeyan, G.; Kasaeian, A.; Katibeh, M.; Kaul, A.; Kawakami, N.; Kayibanda, J.F.; Keiyoro, P.N.; Kemmer, L.; Kemp, A.H.; Kengne, A.P.; Keren, A.; Kereselidze, M.; Kesavachandran, C.N.; Khader, Y.S.; Khalil, I.A.; Khan, A.R.; Khan, E.A.; Khang, Y-H.; Khera, S.; Khoja, T.A.M.; Kieling, C.; Kim, D.; Kim, Y.J.; Kissela, B.M.; Kissoon, N.; Knibbs, L.D.; Knudsen, A.K.; Kokubo, Y.; Kolte, D.; Kopec, J.A.; Kosen, S.; Koul, P.A.; Koyanagi, A.; Krog, N.H.; Defo, B.K.; Bicer, B.K.; Kudom, A.A.; Kuipers, E.J.; Kulkarni, V.S.; Kumar, G.A.; Kwan, G.F.; Lal, A.; Lal, D.K.; Lalloo, R.; Lallukka, T.; Lam, H.; Lam, J.O.; Langan, S.M.; Lansingh, V.C.; Larsson, A.; Laryea, D.O.; Latif, A.A.; Lawrynowicz, A.E.B.; Leigh, J.; Levi, M.; Li, Y.; Lindsay, M.P.; Lipshultz, S.E.; Liu, P.Y.; Liu, S.; Liu, Y.; Lo, L-T.; Logroscino, G.; Lotufo, P.A.; Lucas, R.M.; Lunevicius, R.; Lyons, R.A.; Ma, S.; Machado, V.M.P.; Mackay, M.T.; MacLachlan, J.H.; Razek, H.M.A.E.; Magdy, M.; Razek, A.E.; Majdan, M.; Majeed, A.; Malekzadeh, R.; Manamo, W.A.A.; Mandisarisa, J.; Mangalam, S.; Mapoma, C.C.; Marcenes, W.; Margolis, D.J.; Martin, G.R.; Martinez-Raga, J.; Marzan, M.B.; Masiye, F.; Mason-Jones, A.J.; Massano, J.; Matzopoulos, R.; Mayosi, B.M.; McGarvey, S.T.; McGrath, J.J.; McKee, M.; McMahon, B.J.; Meaney, P.A.; Mehari, A.; Mehndiratta, M.M.; Mejia-Rodriguez, F.; Mekonnen, A.B.; Melaku, Y.A.; Memiah, P.; Memish, Z.A.; Mendoza, W.; Meretoja, A.; Meretoja, T.J.; Mhimbira, F.A.; Micha, R.; Millear, A.; Miller, T.R.; Mirarefin, M.; Misganaw, A.; Mock, C.N.; Mohammad, K.A.; Mohammadi, A.; Mohammed, S.; Mohan, V.; Mola, G.L.D.; Monasta, L.; Hernandez, J.C.M.; Montero, P.; Montico, M.; Montine, T.J.; Moradi-Lakeh, M.; Morawska, L.; Morgan, K.; Mori, R.; Mozaffarian, D.; Mueller, U.O.; Murthy, G.V.S.; Murthy, S.; Musa, K.I.; Nachega, J.B.; Nagel, G.; Naidoo, K.S.; Naik, N.; Naldi, L.; Nangia, V.; Nash, D.; Nejjari, C.; Neupane, S.; Newton, C.R.; Newton, J.N.; Ng, M.; Ngalesoni, F.N.; de Dieu Ngirabega, J.; Nguyen, Q.L.; Nisar, M.I.; Pete, P.M.N.; Nomura, M.; Norheim, O.F.; Norman, P.E.; Norrving, B.; Nyakarahuka, L.; Ogbo, F.A.; Ohkubo, T.; Ojelabi, F.A.; Olivares, P.R.; Olusanya, B.O.; Olusanya, J.O.; Opio, J.N.; Oren, E.; Ortiz, A.; Osman, M.; Ota, E.; Ozdemir, R.; Pa, M.; Pain, A.; Pandian, J.D.; Pant, P.R.; Papachristou, C.; Park, E-K.; Park, J-H.; Parry, C.D.; Parsaeian, M.; Caicedo, A.J.P.; Patten, S.B.; Patton, G.C.; Paul, V.K.; Pearce, N.; Pedro, J.M.; Stokic, L.P.; Pereira, D.M.; Perico, N.; Pesudovs, K.; Petzold, M.; Phillips, M.R.; Piel, F.B.; Pillay, J.D.; Plass, D.; Platts-Mills, J.A.; Polinder, S.; Pope, C.A.; Popova, S.; Poulton, R.G.; Pourmalek, F.; Prabhakaran, D.; Qorbani, M.; Quame-Amaglo, J.; Quistberg, D.A.; Rafay, A.; Rahimi, K.; Rahimi-Movaghar, V.; Rahman, M.; Rahman, M.H.U.; Rahman, S.U.; Rai, R.K.; Rajavi, Z.; Rajsic, S.; Raju, M.; Rakovac, I.; Rana, S.M.; Ranabhat, C.L.; Rangaswamy, T.; Rao, P.; Rao, S.R.; Refaat, A.H.; Rehm, J.; Reitsma, M.B.; Remuzzi, G.; Resnikoff, S.; Ribeiro, A.L.; Ricci, S.; Blancas, M.J.R.; Roberts, B.; Roca, A.; Rojas-Rueda, D.; Ronfani, L.; Roshandel, G.; Rothenbacher, D.; Roy, A.; Roy, N.K.; Ruhago, G.M.; Sagar, R.; Saha, S.; Sahathevan, R.; Saleh, M.M.; Sanabria, J.R.; Sanchez-Niño, M.D.; Sanchez-Riera, L.; Santos, I.S.; Sarmiento-Suarez, R.; Sartorius, B.; Satpathy, M.; Savic, M.; Sawhney, M.; Schaub, M.P.; Schmidt, M.I.; Schneider, I.J.C.; Schöttker, B.; Schutte, A.E.; Schwebel, D.C.; Seedat, S.; Sepanlou, S.G.; Servan-Mori, E.E.; Shackelford, K.A.; Shaddick, G.; Shaheen, A.; Shahraz, S.; Shaikh, M.A.; Shakh-Nazarova, M.; Sharma, R.; She, J.; Sheikhbahaei, S.; Shen, J.; Shen, Z.; Shepard, D.S.; Sheth, K.N.; Shetty, B.P.; Shi, P.; Shibuya, K.; Shin, M-J.; Shiri, R.; Shiue, I.; Shrime, M.G.; Sigfusdottir, I.D.; Silberberg, D.H.; Silva, D.A.S.; Silveira, D.G.A.; Silverberg, J.I.; Simard, E.P.; Singh, A.; Singh, G.M.; Singh, J.A.; Singh, O.P.; Singh, P.K.; Singh, V.; Soneji, S.; Søreide, K.; Soriano, J.B.; Sposato, L.A.; Sreeramareddy, C.T.; Stathopoulou, V.; Stein, D.J.; Stein, M.B.; Stranges, S.; Stroumpoulis, K.; Sunguya, B.F.; Sur, P.; Swaminathan, S.; Sykes, B.L.; Szoeke, C.E.I.; Tabarés-Seisdedos, R.; Tabb, K.M.; Takahashi, K.; Takala, J.S.; Talongwa, R.T.; Tandon, N.; Tavakkoli, M.; Taye, B.; Taylor, H.R.; Ao, B.J.T.; Tedla, B.A.; Tefera, W.M.; Have, M.T.; Terkawi, A.S.; Tesfay, F.H.; Tessema, G.A.; Thomson, A.J.; Thorne-Lyman, A.L.; Thrift, A.G.; Thurston, G.D.; Tillmann, T.; Tirschwell, D.L.; Tonelli, M.; Topor-Madry, R.; Topouzis, F.; Towbin, J.A.; Traebert, J.; Tran, B.X.; Truelsen, T.; Trujillo, U.; Tura, A.K.; Tuzcu, E.M.; Uchendu, U.S.; Ukwaja, K.N.; Undurraga, E.A.; Uthman, O.A.; Dingenen, R.V.; van Donkelaar, A.; Vasankari, T.; Vasconcelos, A.M.N.; Venketasubramanian, N.; Vidavalur, R.; Vijayakumar, L.; Villalpando, S.; Violante, F.S.; Vlassov, V.V.; Wagner, J.A.; Wagner, G.R.; Wallin, M.T.; Wang, L.; Watkins, D.A.; Weichenthal, S.; Weiderpass, E.; Weintraub, R.G.; Werdecker, A.; Westerman, R.; White, R.A.; Wijeratne, T.; Wilkinson, J.D.; Williams, H.C.; Wiysonge, C.S.; Woldeyohannes, S.M.; Wolfe, C.D.A.; Won, S.; Wong, J.Q.; Woolf, A.D.; Xavier, D.; Xiao, Q.; Xu, G.; Yakob, B.; Yalew, A.Z.; Yan, L.L.; Yano, Y.; Yaseri, M.; Ye, P.; Yebyo, H.G.; Yip, P.; Yirsaw, B.D.; Yonemoto, N.; Yonga, G.; Younis, M.Z.; Yu, S.; Zaidi, Z.; Zaki, M.E.S.; Zannad, F.; Zavala, D.E.; Zeeb, H.; Zeleke, B.M.; Zhang, H.; Zodpey, S.; Zonies, D.; Zuhlke, L.J.; Vos, T.; Lopez, A.D.; Murray, C.J.L. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet, 2016, 388(10053), 1459-1544.
[http://dx.doi.org/10.1016/S0140-6736(16)31012-1] [PMID: 27733281]

Venkata, A.N. Asthma-COPD overlap: Review of diagnosis and management. Curr. Opin. Pulm. Med., 2020, 26(2), 155-161.
[http://dx.doi.org/10.1097/MCP.0000000000000649] [PMID: 31714273]

Cañas, J.A.; Sastre, B.; Rodrigo-Muñoz, J.M.; Fernández-Nieto, M.; Barranco, P.; Quirce, S.; Sastre, J.; Del Pozo, V. Eosinophil-derived exosomes contribute to asthma remodelling by activating structural lung cells. Clin. Exp. Allergy, 2018, 48(9), 1173-1185.
[http://dx.doi.org/10.1111/cea.13122] [PMID: 29451337]

Banno, A.; Reddy, A.T.; Lakshmi, S.P.; Reddy, R.C. PPARs: Key regulators of airway inflammation and potential therapeutic targets in asthma. Nucl. Receptor Res., 2018, 5, e101306.
[http://dx.doi.org/10.11131/2018/101306] [PMID: 29450204]

O’Byrne, P.; Fabbri, L.M.; Pavord, I.D.; Papi, A.; Petruzzelli, S.; Lange, P. Asthma progression and mortality: The role of inhaled corticosteroids. Eur. Respir. J., 2019, 54(1), e1900491.
[http://dx.doi.org/10.1183/13993003.00491-2019] [PMID: 31048346]

Durham, A.L.; Caramori, G.; Chung, K.F.; Adcock, I.M. Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease. Transplant. Res., 2016, 167(1), 192-203.
[http://dx.doi.org/10.1016/j.trsl.2015.08.004] [PMID: 26334389]

McCracken, J.L.; Veeranki, S.P.; Ameredes, B.T.; Calhoun, W.J. Diagnosis and management of asthma in adults: A review. JAMA, 2017, 318(3), 279-290.
[http://dx.doi.org/10.1001/jama.2017.8372] [PMID: 28719697]

Cernak, T.; Dykstra, K.D.; Tyagarajan, S.; Vachal, P.; Krska, S.W. The medicinal chemist’s toolbox for late stage functionalization of drug-like molecules. Chem. Soc. Rev., 2016, 45(3), 546-576.
[http://dx.doi.org/10.1039/C5CS00628G] [PMID: 26507237]

Driscoll, D.; Farnia, S.; Kefalas, P.; Maziarz, R.T. Concise Review: The high cost of high-tech medicine: Planning ahead for market access. Stem Cells Transl. Med., 2017, 6(8), 1723-1729.
[http://dx.doi.org/10.1002/sctm.16-0487] [PMID: 28749065]

Fraga, C.A.; Barreiro, E.J. Medicinal chemistry of N-acylhydrazones: New lead-compounds of analgesic, antiinflammatory and antithrombotic drugs. Curr. Med. Chem., 2006, 13(2), 167-198.
[http://dx.doi.org/10.2174/092986706775197881] [PMID: 16472212]

Rostom, S.A.; Shalaby, M.A.; El-Demellawy, M.A. Polysubstituted pyrazoles, part 5. Synthesis of new 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid hydrazide analogs and some derived ring systems. A novel class of potential antitumor and anti-HCV agents. Eur. J. Med. Chem., 2003, 38(11-12), 959-974.
[http://dx.doi.org/10.1016/j.ejmech.2003.08.003] [PMID: 14642328]

Júnior, W.B.; Alexandre-Moreira, M.S.; Alves, M.A.; Perez-Rebolledo, A.; Parrilha, G.L.; Castellano, E.E.; Piro, O.E.; Barreiro, E.J.; Lima, L.M.; Beraldo, H. Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their zinc(II) complexes. Molecules, 2011, 16(8), 6902-6915.
[http://dx.doi.org/10.3390/molecules16086902] [PMID: 21844840]

Chelucci, R.C.; Dutra, L.A.; Lopes Pires, M.E.; de Melo, T.R.F.; Bosquesi, P.L.; Chung, M.C.; Dos Santos, J.L. Antiplatelet and antithrombotic activities of non-steroidal anti-inflammatory drugs containing an N-acyl hydrazone subunit. Molecules, 2014, 19(2), 2089-2099.
[http://dx.doi.org/10.3390/molecules19022089] [PMID: 24549233]

El-Din, N.S.; Barseem, A. Synthesis, bioactivity and docking study of some new índole-hydrazone derivatives. J. Appl. Pharm. Sci., 2016, 6, 75-83.
[http://dx.doi.org/10.7324/JAPS.2016.601211]

Shen, F.Q.; Wang, Z.C.; Wu, S.Y.; Ren, S.Z.; Man, R.J.; Wang, B.Z.; Zhu, H.L. Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX. Bioorg. Med. Chem. Lett., 2017, 27(16), 3653-3660.
[http://dx.doi.org/10.1016/j.bmcl.2017.07.020] [PMID: 28720504]

Mohsin, N.A.; Ahmad, M. Hybrid organic molecules as antiinammatory agents; a review of structural features and biological activity. Turk. J. Chem., 2018, 42, 1-20.
[http://dx.doi.org/10.3906/kim-1706-58]

Ribeiro, N.E.; Pereira, P.S.; de Oliveira, T.B.; de Arruda Lima, S.M.; Silva, T.M.S.; Santana, A.L.B.D.; do Nascimento, M.S.; Santisteban, R.M.; Teixeira, A.A.C.; da Silva, T.G. Acute and repeated dose 28-day oral toxicity of Chrysobalanusicaco L. leaf aqueous extract. Regul. Toxicol. Pharmacol., 2020, 113, 104643.
[http://dx.doi.org/10.1016/j.yrtph.2020.104643] [PMID: 32199870]

OECD - Guidelines for the Testing of Chemicals. OECD 423. Acute oral toxicitY-acute toxic class method; organisation for economic cooperation and development: Paris. 2001.

Bezerra-Santos, C.R.; Vieira-de-Abreu, A.; Barbosa-Filho, J.M.; Bandeira-Melo, C.; Piuvezam, M.R.; Bozza, P.T. Anti-allergic properties of Cissampelos sympodialis and its isolated alkaloid warifteine. Int. Immunopharmacol., 2006, 6(7), 1152-1160.
[http://dx.doi.org/10.1016/j.intimp.2006.02.007] [PMID: 16714219]

de Barros Alves, G.M.; de Sousa Maia, M.B.; de Souza Franco, E.; Galvão, A.M.; da Silva, T.G.; Gomes, R.M.; Martins, M.B.; da Silva Falcão, E.P.; de Castro, C.M.; da Silva, N.H. Expectorant and antioxidant activities of purified fumarprotocetraric acid from Cladonia verticillaris lichen in mice. Pulm. Pharmacol. Ther., 2014, 27(2), 139-143.
[http://dx.doi.org/10.1016/j.pupt.2013.07.002] [PMID: 23872116]

Melgert, B.N.; Postma, D.S.; Kuipers, I.; Geerlings, M.; Luinge, M.A.; van der Strate, B.W.A.; Kerstjens, H.A.M.; Timens, W.; Hylkema, M.N. Female mice are more susceptible to the development of allergic airway inflammation than male mice. Clin. Exp. Allergy, 2005, 35(11), 1496-1503.
[http://dx.doi.org/10.1111/j.1365-2222.2005.02362.x] [PMID: 16297148]

Takeda, M.; Tanabe, M.; Ito, W.; Ueki, S.; Konnno, Y.; Chihara, M.; Itoga, M.; Kobayashi, Y.; Moritoki, Y.; Kayaba, H.; Chihara, J. Gender difference in allergic airway remodelling and immunoglobulin production in mouse model of asthma. Respirology, 2013, 18(5), 797-806.
[http://dx.doi.org/10.1111/resp.12078] [PMID: 23490273]

Lee, K.S.; Kim, S.R.; Park, S.J.; Min, K.H.; Lee, K.Y.; Jin, S.M.; Yoo, W.H.; Lee, Y.C. Antioxidant down-regulates interleukin-18 expression in asthma. Mol. Pharmacol., 2006, 70(4), 1184-1193.
[http://dx.doi.org/10.1124/mol.106.024737] [PMID: 16822930]

Motohiro, A.; Furukawa, T.; Yasumoto, K.; Inokuchi, K. Mechanisms involved in acute lung edema induced in dogs by oleic acid. Eur. Surg. Res., 1986, 18(1), 50-57.
[http://dx.doi.org/10.1159/000128505] [PMID: 3510875]

Lossos, I.S.; Izbicki, G.; Or, R.; Goldstein, R.H.; Breuer, R. The effect of suramin on bleomycin-induced lung injury. Life Sci., 2000, 67(23), 2873-2881.
[http://dx.doi.org/10.1016/S0024-3205(00)00865-1] [PMID: 11106002]

Arnaud, R.R.; Soares, M.S.M.; Santos, M.G.C.; Lira, C.C. Density of mast cells in lesions of actinic cheilitis. Rev. Cubana Estomatol., 2014, 51, 378-387.

Heinemann, F.; Birk, G.; Schoenberger, T.; Stierstorfer, B. Deep neural network based histological scoring of lung fibrosis and inflammation in the mouse model system. PLoS One, 2018, 13(8), e0202708.
[http://dx.doi.org/10.1371/journal.pone.0202708] [PMID: 30138413]

Murakami, K.; Kohno, M.; Kadoya, M.; Nagahara, H.; Fujii, W.; Seno, T.; Yamamoto, A.; Oda, R.; Fujiwara, H.; Kubo, T.; Morita, S.; Nakada, H.; Hla, T.; Kawahito, Y. Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model. PLoS One, 2014, 9(9), e106792.
[http://dx.doi.org/10.1371/journal.pone.0106792] [PMID: 25198418]

Palla, G.; Pelizzi, C.; Predieri, G.; Vignali, C. Conformational study on N-acylhydrazones of aromatic aldehydes by NMR spectroscopy. Gazz. Chim. Ital., 1982, 112, 339-341.

Palla, G.; Predieri, G.; Domiano, P.; Vignali, C.; Turner, W. Conformational behaviour and E/Z isomerization of N-acyl and N-aroylhydrazones. Tetrahedron, 1986, 42(13), 3649-3654.
[http://dx.doi.org/10.1016/S0040-4020(01)87332-4]

Rahman, V.P.; Mukhtar, S.; Ansari, W.H.; Lemiere, G. Synthesis, stereochemistry and biological activity of some novel long alkyl chain substituted thiazolidin-4-ones and thiazan-4-one from 10-undecenoic acid hydrazide. Eur. J. Med. Chem., 2005, 40(2), 173-184.
[http://dx.doi.org/10.1016/j.ejmech.2004.10.003] [PMID: 15694652]

Tian, B.; He, M.; Tang, S.; Hewlett, I.; Tan, Z.; Li, J.; Jin, Y.; Yang, M. Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein. Bioorg. Med. Chem. Lett., 2009, 19(8), 2162-2167.
[http://dx.doi.org/10.1016/j.bmcl.2009.02.116] [PMID: 19297155]

Quattropani, A.; Dorbais, J.; Covini, D.; Pittet, P.A.; Colovray, V.; Thomas, R.J.; Coxhead, R.; Halazy, S.; Scheer, A.; Missotten, M.; Ayala, G.; Bradshaw, C.; De Raemy-Schenk, A.M.; Nichols, A.; Cirillo, R.; Tos, E.G.; Giachetti, C.; Golzio, L.; Marinelli, P.; Church, D.J.; Barberis, C.; Chollet, A.; Schwarz, M.K. Discovery and development of a new class of potent, selective, orally active oxytocin receptor antagonists. J. Med. Chem., 2005, 48(24), 7882-7905.
[http://dx.doi.org/10.1021/jm050645f] [PMID: 16302826]

Lopes, A.B.; Miguez, E.; Kümmerle, A.E.; Rumjanek, V.M.; Fraga, C.A.M.; Barreiro, E.J. Characterization of amide bond conformers for a novel heterocyclic template of N-acylhydrazone derivatives. Molecules, 2013, 18(10), 11683-11704.
[http://dx.doi.org/10.3390/molecules181011683] [PMID: 24071978]

Nguyen, B.T.; Anslyn, E.V. Indicator-displacement assays. Coord. Chem. Rev., 2006, 250(23-24), 3118-3127.
[http://dx.doi.org/10.1016/j.ccr.2006.04.009]

Woutersen, M.; Muller, A.; Pronk, M.E.J.; Cnubben, N.H.P.; Hakkert, B.C. Regulating human safety: How dose selection in toxicity studies impacts human health hazard assessment and subsequent risk management options. Regul. Toxicol. Pharmacol., 2020, 114, 104660.
[http://dx.doi.org/10.1016/j.yrtph.2020.104660] [PMID: 32334039]

Sookvanichsilp, N.; Nakornchai, S.; Weerapradist, W. Toxicological study of pyridoxal isonicotinoyl hydrazone: Acute and subchronic toxicity. Drug Chem. Toxicol., 1991, 14(4), 395-403.
[http://dx.doi.org/10.3109/01480549109011641] [PMID: 1811960]

Jayalakshmi, N.; Nanjundan, S. Synthesis, characterization and pharmacological studies of selenadiazole and hydrazone derivatives of 2, 6–diphenyl –4–piperidone. Int. J. Chem. Sci., 2008, 6, 1177-1188.

Boonpiyathad, T.; Sözener, Z.C.; Satitsuksanoa, P.; Akdis, C.A. Immunologic mechanisms in asthma. Semin. Immunol., 2019, 46, 101333.
[http://dx.doi.org/10.1016/j.smim.2019.101333] [PMID: 31703832]

Agra, L.C.; Lins, M.P.; da Silva Marques, P.; Smaniotto, S.; Bandeira de Melo, C.; Lagente, V.; Barreto, E. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice. Eur. J. Pharmacol., 2016, 780, 232-242.
[http://dx.doi.org/10.1016/j.ejphar.2016.03.056] [PMID: 27038519]

Sousa, L.P.; Carmo, A.F.; Rezende, B.M.; Lopes, F.; Silva, D.M.; Alessandri, A.L.; Bonjardim, C.A.; Rossi, A.G.; Teixeira, M.M.; Pinho, V.; Pinho, V. Cyclic AMP enhances resolution of allergic pleurisy by promoting inflammatory cell apoptosis via inhibition of PI3K/Akt and NF-kappaB. Biochem. Pharmacol., 2009, 78(4), 396-405.
[http://dx.doi.org/10.1016/j.bcp.2009.04.030] [PMID: 19422809]

Zimecki, M.; Artym, J.; Kocięba, M.; Kaleta-Kuratewicz, K.; Kruzel, M.L. Lactoferrin restrains allergen-induced pleurisy in mice. Inflamm. Res., 2012, 61(11), 1247-1255.
[http://dx.doi.org/10.1007/s00011-012-0522-y] [PMID: 22810368]

Reis, A.C.; Alessandri, A.L.; Athayde, R.M.; Perez, D.A.; Vago, J.P.; Ávila, T.V.; Ferreira, T.P.T.; de Arantes, A.C.; Coutinho, D.S.; Rachid, M.A.; Sousa, L.P.; Martins, M.A.; Menezes, G.B.; Rossi, A.G.; Teixeira, M.M.; Pinho, V. Induction of eosinophil apoptosis by hydrogen peroxide promotes the resolution of allergic inflammation. Cell Death Dis., 2015, 6(2), e1632.
[http://dx.doi.org/10.1038/cddis.2014.580] [PMID: 25675292]

Boucher, R.C. Muco-obstructive lung diseases. N. Engl. J. Med., 2019, 380(20), 1941-1953.
[http://dx.doi.org/10.1056/NEJMra1813799] [PMID: 31091375]

Shen, Y.; Huang, S.; Kang, J.; Lin, J.; Lai, K.; Sun, Y.; Xiao, W.; Yang, L.; Yao, W.; Cai, S.; Huang, K.; Wen, F. Management of airway mucus hypersecretion in chronic airway inflammatory disease: Chinese expert consensus (English edition). Int. J. Chron. Obstruct. Pulmon. Dis., 2018, 13, 399-407.
[http://dx.doi.org/10.2147/COPD.S144312] [PMID: 29430174]

Tian, P.W.; Wen, F.Q. Clinical significance of airway mucus hypersecretion in chronic obstructive pulmonary disease. J. Transl. Int. Med., 2015, 3(3), 89-92.
[http://dx.doi.org/10.1515/jtim-2015-0013] [PMID: 27847895]

Allinson, J.P.; Hardy, R.; Donaldson, G.C.; Shaheen, S.O.; Kuh, D.; Wedzicha, J.A. The presence of chronic mucus hypersecretion across adult life in relation to chronic obstructive pulmonary disease development. Am. J. Respir. Crit. Care Med., 2016, 193(6), 662-672.
[http://dx.doi.org/10.1164/rccm.201511-2210OC] [PMID: 26695373]

Gubernatorova, E.O.; Namakanova, O.A.; Tumanov, A.V.; Drutskaya, M.S.; Nedospasov, S.A. Mouse models of severe asthma for evaluation of therapeutic cytokine targeting. Immunol. Lett., 2019, 207, 73-83.
[http://dx.doi.org/10.1016/j.imlet.2018.11.012] [PMID: 30659868]

Vuolo, F.; Abreu, S.C.; Michels, M.; Xisto, D.G.; Blanco, N.G.; Hallak, J.E.C.; Zuardi, A.W.; Crippa, J.A.; Reis, C.; Bahl, M.; Pizzichinni, E.; Maurici, R.; Pizzichinni, M.M.M.; Rocco, P.R.M.; Dal-Pizzol, F. Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma. Eur. J. Pharmacol., 2019, 843, 251-259.
[http://dx.doi.org/10.1016/j.ejphar.2018.11.029] [PMID: 30481497]

Yun, C.; Chang, M.; Hou, G.; Lan, T.; Yuan, H.; Su, Z.; Zhu, D.; Liang, W.; Li, Q.; Zhu, H.; Zhang, J.; Lu, Y.; Deng, J.; Guo, H. Mangiferin suppresses allergic asthma symptoms by decreased Th9 and Th17 responses and increased Treg response. Mol. Immunol., 2019, 114, 233-242.
[http://dx.doi.org/10.1016/j.molimm.2019.07.025] [PMID: 31386980]

McBrien, C.N.; Menzies-Gow, A. The biology of eosinophils and their role in asthma. Front. Med. (Lausanne), 2017, 4, 93.
[http://dx.doi.org/10.3389/fmed.2017.00093] [PMID: 28713812]

Steinsvoll, S.; Helgeland, K.; Schenck, K. Mast cells--a role in periodontal diseases? J. Clin. Periodontol., 2004, 31(6), 413-419.
[http://dx.doi.org/10.1111/j.1600-051X.2004.00516.x] [PMID: 15142208]

Cerqueira, J.V.; Meira, C.S.; Santos, E.S.; de Aragão França, L.S.; Vasconcelos, J.F.; Nonaka, C.K.V.; de Melo, T.L.; Dos Santos Filho, J.M.; Moreira, D.R.M.; Soares, M.B.P. Anti-inflammatory activity of SintMed65, an N-acylhydrazone derivative, in a mouse model of allergic airway inflammation. Int. Immunopharmacol., 2019, 75, 105735.
[http://dx.doi.org/10.1016/j.intimp.2019.105735] [PMID: 31306982]

Nakajima, H.; Iwamoto, I.; Tomoe, S.; Matsumura, R.; Tomioka, H.; Takatsu, K.; Yoshida, S. CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am. Rev. Respir. Dis., 1992, 146(2), 374-377.
[http://dx.doi.org/10.1164/ajrccm/146.2.374] [PMID: 1362635]

Kips, J.C.; Brusselle, G.G.; Joos, G.F.; Peleman, R.A.; Devos, R.R.; Tavernier, J.H.; Pauwels, R.A. Importance of interleukin-4 and interleukin-12 in allergen-induced airway changes in mice. Int. Arch. Allergy Immunol., 1995, 107(1-3), 115-118.
[http://dx.doi.org/10.1159/000236947] [PMID: 7613115]

Foster, P.S.; Hogan, S.P.; Ramsay, A.J.; Matthaei, K.I.; Young, I.G. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med., 1996, 183(1), 195-201.
[http://dx.doi.org/10.1084/jem.183.1.195] [PMID: 8551223]

Hamelmann, E.; Schwarze, J.; Takeda, K.; Oshiba, A.; Larsen, G.L.; Irvin, C.G.; Gelfand, E.W. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am. J. Respir. Crit. Care Med., 1997, 156(3 Pt 1), 766-775.
[http://dx.doi.org/10.1164/ajrccm.156.3.9606031] [PMID: 9309991]

Mattes, J.; Yang, M.; Mahalingam, S.; Kuehr, J.; Webb, D.C.; Simson, L.; Hogan, S.P.; Koskinen, A.; McKenzie, A.N.; Dent, L.A.; Rothenberg, M.E.; Matthaei, K.I.; Young, I.G.; Foster, P.S. Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J. Exp. Med., 2002, 195(11), 1433-1444.
[http://dx.doi.org/10.1084/jem.20020009] [PMID: 12045241]

Hall, S.; Agrawal, D.K. Key mediators in the immunopathogenesis of allergic asthma. Int. Immunopharmacol., 2014, 23(1), 316-329.
[http://dx.doi.org/10.1016/j.intimp.2014.05.034] [PMID: 24933589]

Duvall, M.G.; Krishnamoorthy, N.; Levy, B.D. Non-type 2 inflammation in severe asthma is propelled by neutrophil cytoplasts and maintained by defective resolution. Allergol. Int., 2019, 68(2), 143-149.
[http://dx.doi.org/10.1016/j.alit.2018.11.006] [PMID: 30573389]

Hernandez, J.D.; Yu, M.; Sibilano, R.; Tsai, M.; Galli, S.J. Development of multiple features of antigen-induced asthma pathology in a new strain of mast cell deficient BALB/c-KitW-sh/W-sh mice. Lab. Invest., 2020, 100(4), 516-526.
[http://dx.doi.org/10.1038/s41374-019-0354-2] [PMID: 31857699]

Reber, L.L.; Fahy, J.V. Mast cells in asthma: Biomarker and therapeutic target. Eur. Respir. J., 2016, 47, 1040-1042.
[http://dx.doi.org/10.1183/13993003.00065-2016]

Bentley, A.M.; Hamid, Q.; Robinson, D.S.; Schotman, E.; Meng, Q.; Assoufi, B.; Kay, A.B.; Durham, S.R. Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa. Am. J. Respir. Crit. Care Med., 1996, 153(2), 551-556.
[http://dx.doi.org/10.1164/ajrccm.153.2.8564096] [PMID: 8564096]

James, A.L.; Maxwell, P.S.; Pearce-Pinto, G.; Elliot, J.G.; Carroll, N.G. The relationship of reticular basement membrane thickness to airway wall remodeling in asthma. Am. J. Respir. Crit. Care Med., 2002, 166(12 Pt 1), 1590-1595.
[http://dx.doi.org/10.1164/rccm.2108069] [PMID: 12471074]

Raymond, M.; Ching-A-Sue, G.; Van Hecke, O. Mast cell stabilisers, leukotriene antagonists and antihistamines: A rapid review of the evidence for their use in COVID19; Centre Evid-Based Med, 2020.

Anderson, S.D.; Caillaud, C.; Brannan, J.D. β2-agonists and exercise-induced asthma. Clin. Rev. Allergy Immunol., 2006, 31(2-3), 163-180.
[http://dx.doi.org/10.1385/CRIAI:31:2:163] [PMID: 17085791]

Makhija, I.K.; Shreedhara, C.S.; Ram, H.N. Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation. Pharmacognosy Res., 2013, 5(4), 306-308.
[http://dx.doi.org/10.4103/0974-8490.118824] [PMID: 24174826]

You, X-Y.; Xue, Q.; Fang, Y.; Liu, Q.; Zhang, C.F.; Zhao, C.; Zhang, M.; Xu, X-H. Preventive effects of Ecliptae Herba extract and its component, ecliptasaponin A, on bleomycin-induced pulmonary fibrosis in mice. J. Ethnopharmacol., 2015, 175, 172-180.
[http://dx.doi.org/10.1016/j.jep.2015.08.034] [PMID: 26385580]

Xiang, J.; Cheng, S.; Feng, T.; Wu, Y.; Xie, W.; Zhang, M.; Xu, X.; Zhang, C. Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages. Int. Immunopharmacol., 2016, 36, 158-164.
[http://dx.doi.org/10.1016/j.intimp.2016.04.016] [PMID: 27144994]

Wang, X.; Ouyang, Z.; You, Q.; He, S.; Meng, Q.; Hu, C.; Wu, X.; Shen, Y.; Sun, Y.; Wu, X.; Xu, Q. Obaculactone protects against bleomycin-induced pulmonary fibrosis in mice. Toxicol. Appl. Pharmacol., 2016, 303(303), 21-29.
[http://dx.doi.org/10.1016/j.taap.2016.05.005] [PMID: 27180239]

Liu, Y.L.; Chen, B.Y.; Nie, J.; Zhao, G.H.; Zhuo, J.Y.; Yuan, J.; Li, Y.C.; Wang, L.L.; Chen, Z.W. Polydatin prevents bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β/Smad/ERK signaling pathway. Exp. Ther. Med., 2020, 20(5), 62.
[http://dx.doi.org/10.3892/etm.2020.9190] [PMID: 32952652]

Abidi, A.; Bahri, S.; Khamsa, S.B.; Legrand, A. Nigella sativa fixed oil, attenuates bleomycin-induced pulmonary fibrosis in a rat model. Eur. Respir. J., 2018, 52, PA4796.
[http://dx.doi.org/10.1183/13993003.congress-2018.PA4796]

Ruan, Q.; Yang, K.; Wang, W.; Jiang, L.; Song, J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Int. Care Med., 2020, 46(5), 846-848.
[http://dx.doi.org/10.1007/s00134-020-05991-x] [PMID: 32125452]

Winters, N.I.; Burman, A.; Kropski, J.A.; Blackwell, T.S. Epithelial injury and dysfunction in the pathogenesis of idiopathic pulmonary fibrosis. Am. J. Med. Sci., 2019, 357(5), 374-378.
[http://dx.doi.org/10.1016/j.amjms.2019.01.010] [PMID: 31010463]

Weiskirchen, R.; Weiskirchen, S.; Tacke, F. Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications. Mol. Aspects Med., 2019, 65, 2-15.
[http://dx.doi.org/10.1016/j.mam.2018.06.003] [PMID: 29958900]

Hu, X.; Xu, Q.; Wan, H.; Hu, Y.; Xing, S.; Yang, H.; Gao, Y.; He, Z. PI3K-Akt-mTOR/PFKFB3 pathway mediated lung fibroblast aerobic glycolysis and collagen synthesis in lipopolysaccharide-induced pulmonary fibrosis. Lab. Invest., 2020, 100(6), 801-811.
[http://dx.doi.org/10.1038/s41374-020-0404-9] [PMID: 32051533]

Baddini-Martinez, J.; Baldi, B.G.; Costa, C.H.; Jezler, S.; Lima, M.S.; Rufino, R. Update on diagnosis and treatment of idiopathic pulmonary fibrosis. J. Bras. Pneumol., 2015, 41(5), 454-466.
[http://dx.doi.org/10.1590/S1806-37132015000000152] [PMID: 26578138]

Knüppel, L.; Ishikawa, Y.; Aichler, M.; Heinzelmann, K.; Hatz, R.; Behr, J.; Walch, A.; Bächinger, H.P.; Eickelberg, O.; Staab-Weijnitz, C.A. A novel antifibrotic mechanism of nintedanib and pirfenidone. Am. J. Respir. Cell Mol. Biol., 2017, 57(1), 77-90.
[http://dx.doi.org/10.1165/rcmb.2016-0217OC] [PMID: 28257580]