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摘要
糖尿病肾病(DN)是糖尿病的严重并发症,也是终晚肾病(ESRD)的主要原因之一。导致DN进展的因素很多。脂质代谢紊乱是DN的常见临床表现,异位肾脂质沉积最近被认为是促进DN发展的关键因素。脂质吞噬是一种新发现的选择性自噬,可以清除细胞中过量的脂质以维持脂质稳态。最近,嗜脂性异常也与DN的进展有关。在这里,我们讨论了脂滴的形成,描述了亲脂性及其关键调节信号,总结了目前DN中亲脂性的研究进展,最后提出亲脂性可能是治疗DN的潜在靶点。
关键词: 糖尿病肾病(DN),嗜脂性,脂滴,脂质稳态,自噬,肾脏。
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