Title:Naturally Occurring Compounds as Potential Inhibitors of Epidermal
Growth Factor Receptors (EGFRs)
Volume: 26
Issue: 6
Author(s): Listiana Oktavia*, Asrul Muhamad Fuad*, Seni Kurnia Senjaya and Yuliawati Yuliyawati
Affiliation:
- Department of Chemistry, Research Center for Pharmaceutical Ingredient and Traditional Medicine, National
Research and Innovation Agency (BRIN), Cibinong, Bogor, Jawa Barat, 16911, Indonesia
- Department of
Biotechnology, Research Center for Genetic Engineering, National Research and Innovation Agency (BRIN), Cibinong,
Bogor, Jawa Barat, 16911, Indonesia
Keywords:
Cancer, chemotherapy, EGFR, inhibitor, natural products, TNBC.
Abstract: The Epidermal Growth Factor Receptor (EGFR) activation appears essential in tumor
growth and progression. Targeting EGFR signaling pathway has become an exciting area in cancer
therapy. Synthetic chemotherapy drugs have been used to inhibit some EGFR signaling in various
cancer cells. The use of naturally occurring compounds as EGFR inhibitors is an attractive area for
research due to the urgent need to combat resistance over current EGFR inhibitors. In this review,
we first summarize the schematic role of EGFR in cancer and the current EGFR inhibitor used, its
advantage, and disadvantage. Next, we discuss the natural products that have been reported as the
source of EGFR inhibitors. The discussion covers the natural products which where majorly
reported from the year 2005-2020. A total of 21 groups of natural compounds and their derivatives
were reported to have the potential to inhibit EGFR signaling pathways. We then discuss the
advanced technologies and approaches that rapidly discover EGFR inhibitor-based natural
products. Hopefully, this literature review could increase the excitement of finding an effective
EGFR pathway inhibitor from natural products.