Title:Tertiary Nanosystem Composed of Graphene Quantum Dots, Levofloxacin
and Silver Nitrate for Microbiological Control
Volume: 16
Issue: 3
Author(s): Thamires Oliveira Vieira, Eduardo Ricci-Junior, Aline Oiveira da Silva de Barros, Luciana Magalhães Rebelo Alencar, Marcia Regina Spuri Ferreira, Terezinha de Jesus Andreoli Pinto, Ralph Santos-Oliveira*Diego de Holanda Saboya Souza
Affiliation:
- Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis
of New Radiopharmaceuticals, Rio de Janeiro 21941906, Brazil
- Zona Oeste State University, Laboratory of Nanoradiopharmaceuticals,
Rio de Janeiro 23070200, Brazil;
Keywords:
Drug delivery, bacterial, multi-drug resistance, antibacterial, ultrasonication, nanosystem.
Abstract:
Background: Infectious diseases have the highest mortality rate in the world and these
numbers are associated with scarce and/or ineffective diagnosis and bacterial resistance. Currently,
with the development of new pharmaceutical formulations, nanotechnology is gaining prominence.
Methods: Nanomicelles were produced by ultrasonication. The particle size and shape were evaluated
by scanning electron microscopy and confirmed by dynamic light scattering, also thermogravimetric
analysis was performed to evaluate the thermal stability. Finally, antibacterial activity has been performed.
Results: The results showed that a rod-shaped nanosystem, with 316.1 nm and PDI of 0.243 was
formed. The nanosystem was efficient against Staphylococcus aureus, Pseudomonas aeruginosa, and
Bacillus subtilis subsp. spizizenii with MIC inferior to 0.98 and a synergistic effect between silver graphene
quantum dots and levofloxacin was observed.
Conclusion: The nanosystem produced may rise as a promising agent against the bacterial threat, especially
regarding bacterial resistance.
