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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Mini-Review Article

The Synthesis of Australine and its Stereoisomers as Naturally Pyrrolizidine Alkaloids

Author(s): Ghodsi Mohammadi Ziarani*, Negar Jamasbi and Fatemeh Mohajer

Volume 21, Issue 1, 2024

Published on: 03 October, 2022

Page: [40 - 57] Pages: 18

DOI: 10.2174/1570193X19666220704115936

Price: $65

Abstract

Natural products are important from the researchers’ perspectives due to their importance and applicability. Polyhydroxylated pyrrolizidine alkaloids are sugar mimics and received a growing interest in the last few years. Australine is a naturally polyhydroxylated pyrrolizidine, which was isolated from the seeds of Castanospermum austral, and exhibits potent biological activities such as inhibited glycosidases, as well as anti-virus, and anti-HIV activities. Thus, there is a considerable deal of interest in the synthesis of these classes of compounds. Different synthetic strategies and methodologies for the preparation of Australine and its stereoisomers were considered.

Keywords: Polyhydroxylated pyrrolizidine, alkaloids, australine, natural products, castanospermum austral, stereoisomers.

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Graphical Abstract

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